CAJ | 학술논문

目的：观察西酞普兰对冠心病伴抑郁症患者内皮功能的影响，进一步评价西酞普兰的临床疗效及其机制。方法将2007年9月-2009年2月住本院心内科120例确诊为冠心病合并抑郁症患者随机分为对照组（n ＝55）和治疗组（n ＝58），2组患者均给予冠心病常规治疗加心理干预，治疗组患者加用西酞普兰20 mg /晚，2组患者于治疗前及治疗8周末进行汉密尔顿抑郁量表评分及内皮功能测定。结果治疗8周后，治疗组 HAMD 评分（7．60±3．49）与对照组评分（20．58±3．20）比较，差异有统计学意义（P ＜0．01）；治疗组血流介导的内皮依赖性血管扩张（FMD）值（4．69±0．58）与对照组（4．45±0．69）比较，差异有统计学意义（P ＜0．05）。结论西酞普兰可以明显改善冠心病症合并抑郁患者的抑郁症状，改善患者的内皮功能。
목적：관찰서태보란대관심병반억욱증환자내피공능적영향，진일보평개서태보란적림상료효급기궤제。방법장2007년9월-2009년2월주본원심내과120례학진위관심병합병억욱증환자수궤분위대조조（n ＝55）화치료조（n ＝58），2조환자균급여관심병상규치료가심리간예，치료조환자가용서태보란20 mg /만，2조환자우치료전급치료8주말진행한밀이돈억욱량표평분급내피공능측정。결과치료8주후，치료조 HAMD 평분（7．60±3．49）여대조조평분（20．58±3．20）비교，차이유통계학의의（P ＜0．01）；치료조혈류개도적내피의뢰성혈관확장（FMD）치（4．69±0．58）여대조조（4．45±0．69）비교，차이유통계학의의（P ＜0．05）。결론서태보란가이명현개선관심병증합병억욱환자적억욱증상，개선환자적내피공능。
Objective To study The effect of anti-depression treatment on endothelial function of coronary artery disease (CAD)and depressive disorder.Methods 120 CAD patients with depressive disorder treated in our hospital from September 2007 to February 2009 were ran-domized to control group (n =58)and treatment group (n =62).The patients in both groups were given conventional treatment and psychological intervention,and the patients in treatment group were added 20 mg Citalopram tablets every night.Scores of Hamilton Depression Rating Scale(HAMD)of the patients were measured and endothelial function of the patients were evaluated at 8 weeks before and after the treatment.Results After 8 week treatment,the HAMD score was (7.60±3.49)in treatment group and (20.58±3.20)in control group,the difference was signifi-cant after comparison of two groups (P <0.01).The values of FMD% were respectively (4.69± 0.58)in treatment group and (4.45±0.69)in control group which revealed that the difference was significant (P <0.05).Conclusion Citalopram can significantly improve depression and en-dothelial function of CAD patients with depression.