CAJ | 학술논문

目的：对血管紧张素Ⅱ对冠心病患者血浆脂联素水平的影响进行观察和分析。方法以本院心内科2011-2012年收治的56例冠心病患者和48例健康者作为研究对象，分别对其进行血浆脂联素水平的检测，并对结果进行比较分析。结果①2组患者在性别、年龄、血糖、血压、（血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）差异均无统计学意义（P ＞0．05），而观察组患者脂联素和血管紧张素Ⅱ水平则显著高于对照组（P ＜0．01）；②观察组中急性冠脉综合征（ACS）和稳定性心绞痛（SAP）患者的血管紧张素Ⅱ水平均明显高于对照组，SAP 患者的脂联素水平高于对照组，而 ACS 患者其脂联素明显低于对照组患者和 SAP 患者（P ＜0．05），差异均具有统计学意义。结论血管紧张素Ⅱ和脂联素水平变化与冠心病发病以及冠脉的稳定性有着密切的关系，临床可通过抑制血管紧张素Ⅱ的生成，促进脂联素的分泌，起到提高冠脉稳定性的作用。
목적：대혈관긴장소Ⅱ대관심병환자혈장지련소수평적영향진행관찰화분석。방법이본원심내과2011-2012년수치적56례관심병환자화48례건강자작위연구대상，분별대기진행혈장지련소수평적검측，병대결과진행비교분석。결과①2조환자재성별、년령、혈당、혈압、（혈청총담고순（TC）화저밀도지단백담고순（LDL-C）차이균무통계학의의（P ＞0．05），이관찰조환자지련소화혈관긴장소Ⅱ수평칙현저고우대조조（P ＜0．01）；②관찰조중급성관맥종합정（ACS）화은정성심교통（SAP）환자적혈관긴장소Ⅱ수평균명현고우대조조，SAP 환자적지련소수평고우대조조，이 ACS 환자기지련소명현저우대조조환자화 SAP 환자（P ＜0．05），차이균구유통계학의의。결론혈관긴장소Ⅱ화지련소수평변화여관심병발병이급관맥적은정성유착밀절적관계，림상가통과억제혈관긴장소Ⅱ적생성，촉진지련소적분비，기도제고관맥은정성적작용。
Objective To explore the correlation between angiotensin Ⅱ and the levels of plasma adiponectin in patients with coronary heart disease (CHD).Methods 56 patients with CHD and 48 healthy peoples were collected as research object,and the plasma adiponectin levels were detected and compared between two groups.Results There were no significant differences of gender,age,blood glucose,blood pressure,TC and LDL-C between two groups (P >0.05), but adiponectin and angiotensin Ⅱ levels of the observation group were significantly higher than those of control group (P <0.01).The angiotensin Ⅱ levels in ACS and SAP patients of observa-tion group were significantly higher than that of control group,the adiponectin level of SAP pa-tients was higher than that of the control group,and the adiponectin level of ACS patients was sig-nificantly lower than that of the control group and SAP patients(P <0.05).Conclusion There is a close relationship between levels of angiotensin Ⅱ,adiponectin and the attack of the coronary dis-ease,the stability of the coronary artery.In the clinic,physicians can inhibit the formation of an-giotensin Ⅱ to promote the secretion of adiponectin and improve the stability of coronary artery.