CAJ | 학술논문

目的探讨Narcotrend用于咪达唑仑镇静深度监测的可靠性及镇静深度[改良警觉镇静评分(OAA/S)]与Narcotrend指数的相关性.方法选择ASA Ⅰ～Ⅱ级择期行椎管内麻醉下下肢手术患者60例,给予静脉靶控输注咪达唑仑,血浆靶控浓度从50 ng/ml开始,以10 ng/ml的梯度逐步升高目标浓度,每一阶段维持5 min,当OAA/S评分为1分时停药,观察至OAA/S评分达5分,若手术尚未结束,调控至合适的镇静深度直至手术结束,记录不同OAA/S评分时的Narcotrend指数、心率、平均动脉压、呼吸的变化.结果镇静加深期、恢复期OAA/S评分与Narcotrend指数均显著相关(r=0.786、0.652,均P＜0.05).结论 Narcotrend 能很好指导咪达唑仑靶控输注,其指数与咪达唑仑镇静深度密切相关.
목적 탐토Narcotrend용우미체서륜진정심도감측적가고성급진정심도[개량경각진정평분(OAA/S)]여Narcotrend지수적상관성.방법 선택ASA Ⅰ～Ⅱ급택기행추관내마취하하지수술환자60례,급여정맥파공수주미체서륜,혈장파공농도종50 ng/ml개시,이10 ng/ml적제도축보승고목표농도,매일계단유지5 min,당OAA/S평분위1분시정약,관찰지OAA/S평분체5분,약수술상미결속,조공지합괄적진정심도직지수술결속,기록불동OAA/S평분시적Narcotrend지수、심솔、평균동맥압、호흡적변화.결과 진정가심기、회복기OAA/S평분여Narcotrend지수균현저상관(r=0.786、0.652,균P＜0.05).결론 Narcotrend 능흔호지도미체서륜파공수주,기지수여미체서륜진정심도밀절상관.
Objective To investigate the reliability of Narcotrend for monitoring the depth of sedation [the observer's assessment of alterness/sedation(OAA/S) scale] with midazolam and correlation between the depth of sedation and Narcotrend index.Methods 0 ASA Ⅰ-Ⅱ status patients scheduled for elective lower limb operations underwent spinal anesthesia,who were given target-controlled infusion of midazolam.Target plasma concentration was 50ng/ ml at first and increased by 10 ng/ml each grade until OAA/S scale became 1 point.Each target concentration infusion was maintained for 5min.Observe the patient the OAA/S scale to be 5 points.If the operation was not over yet,regulated the appropriate depth of sedation until the end of operation.The Narcotrend index of different OAA/S scale and heart rate,mean arterial pressure,respiration were recorded.Results In the deepening or recovery phase of sedation,OAA/S scales were correlated with Narcotrend index (Spearman' s r =0.786,0.652,all P ＜ 0.05).Conclusion Narcotrend is a good index to guide target controlled infusion of midazolam,the index is closely related with the depth of sedation of midazolam.