广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2012年
21期
89-90,97
,共3页
N1,N3-二苯甲酰基-5-氟尿嘧啶%合成%方法改进
N1,N3-二苯甲酰基-5-氟尿嘧啶%閤成%方法改進
N1,N3-이분갑선기-5-불뇨밀정%합성%방법개진
N1%N3-dibenzoyl-5-fluorouracil%synthesis%improvement
5-氟尿嘧啶衍生物在医药及化工行业中的应用非常广泛。本文改进以苯甲酸和5-氟尿嘧啶为原料合成N1,N3-二苯甲酰基-5-氟尿嘧啶的方法,经质谱、核磁共振波谱以及红外光谱确证了产物结构,并采用正交试验优化反应条件。经优化,该法使产率从原来的30%提高到79.9%,且后处理简便。
5-氟尿嘧啶衍生物在醫藥及化工行業中的應用非常廣汎。本文改進以苯甲痠和5-氟尿嘧啶為原料閤成N1,N3-二苯甲酰基-5-氟尿嘧啶的方法,經質譜、覈磁共振波譜以及紅外光譜確證瞭產物結構,併採用正交試驗優化反應條件。經優化,該法使產率從原來的30%提高到79.9%,且後處理簡便。
5-불뇨밀정연생물재의약급화공행업중적응용비상엄범。본문개진이분갑산화5-불뇨밀정위원료합성N1,N3-이분갑선기-5-불뇨밀정적방법,경질보、핵자공진파보이급홍외광보학증료산물결구,병채용정교시험우화반응조건。경우화,해법사산솔종원래적30%제고도79.9%,차후처리간편。
5-fluorouracil derivatives had important sense on production in industry and medical vocation.The synthesis technology of N1,N3-dibenzoyl-5-fluorouracil using benzoic acid and 5-fluorouracil as row materials was improved.The improved method made the yield increase from 30% to 79.9% and simplified the post-treatment.Structure of the compound was identified by HRMS,1H NMR,13C NMR,and IR,and orthogonal test was used to explore the optimum reaction conditions.
