CAJ | 학술논문

目的：观察比较两种不同注射剂量的A型肉毒毒素（BTX-A）行额部注射除皱术后，引起局部皮脂分泌改变的情况，并研究其剂量和功效之间的关联。方法20例额部皱纹患者（中度至重度）随机分为注射总量10 U或20 U的两个治疗组。注射药物为宝妥适(BOTOX, BOTOX Cosmetic；Allergan, Irvine, CA)，使用肌肉内注射标准五点法。评价注射后2周、4周、8周、16周患者额部注射区域（注射点外围半径0.5 cm区域、注射点外围半径0.6～1.5 cm环形区域、注射点外围半径1.6～2.5 cm环形区域）皮肤油脂分泌水平。结果两种不同剂量注射2周、4周、8周后额部注射点外围半径0.5 cm区域平均皮脂分泌水平较注射前显著下降（P＜0.05），注射16周后注射点外围半径0.5 cm区域平均油脂分泌水平于注射前相比没有显著差异。注射2周、4周、8周、16周后，注射点外围半径1.6～2.5 cm环形区域皮肤的平均油脂分泌水平显著高于注射前平均皮肤油脂分泌水平（P＜0.05），注射点外围半径1.6～2.5 cm环形区域皮肤的平均油脂分泌水平与注射前水平相比没有显著的统计学差异。结论10 U及20 U肌肉内BTX-A注射2周、4周及8周后，能显著减少注射点外围半径0.5 cm区域的皮脂分泌，并引起注射点外围半径1.6～2.5 cm环形区域皮肤的皮脂分泌增高。
목적：관찰비교량충불동주사제량적A형육독독소（BTX-A）행액부주사제추술후，인기국부피지분비개변적정황，병연구기제량화공효지간적관련。방법20례액부추문환자（중도지중도）수궤분위주사총량10 U혹20 U적량개치료조。주사약물위보타괄(BOTOX, BOTOX Cosmetic；Allergan, Irvine, CA)，사용기육내주사표준오점법。평개주사후2주、4주、8주、16주환자액부주사구역（주사점외위반경0.5 cm구역、주사점외위반경0.6～1.5 cm배형구역、주사점외위반경1.6～2.5 cm배형구역）피부유지분비수평。결과량충불동제량주사2주、4주、8주후액부주사점외위반경0.5 cm구역평균피지분비수평교주사전현저하강（P＜0.05），주사16주후주사점외위반경0.5 cm구역평균유지분비수평우주사전상비몰유현저차이。주사2주、4주、8주、16주후，주사점외위반경1.6～2.5 cm배형구역피부적평균유지분비수평현저고우주사전평균피부유지분비수평（P＜0.05），주사점외위반경1.6～2.5 cm배형구역피부적평균유지분비수평여주사전수평상비몰유현저적통계학차이。결론10 U급20 U기육내BTX-A주사2주、4주급8주후，능현저감소주사점외위반경0.5 cm구역적피지분비，병인기주사점외위반경1.6～2.5 cm배형구역피부적피지분비증고。
Objective To compare the efficacy of frontal rhytidectomy by different dosage of botulinum toxin type A on sebum secretion, and to investigate the correlation between the dosage and clinical efficacy. Methods Twenty volunteers with forehead ryhtides (moderate to severe) were received frontal rhytidectomy by BTX-A (BOTOX) intramuscular injection which was administered to 5 injective sites, and randomly divided into 2 groups according to different dosage (group 1:10 U;group 2:20 U). Baseline and post-treatment (2, 4, 6, 8 weeks after injection) sebum production (the region 0.5 cm far around injection point, the region 0.6-1.5 cm far around injection point, the region 1.6-2.5 cm far around injection point) were measured. Results Significant reduction of sebum secretion was showed on the region 0.5 cm far around injection point after BTX-A injection for 2, 4, 8 weeks (P<0.05) and no obvious change of sebum secretion was showed after BTX-A injection for 16 weeks (P>0.05). No significant difference was observed between the two groups. The sebum secretion of the region 1.6-2.5 cm far around injection point was increased after BTX-A injection for 2, 4, 8, 16 weeks ( P<0.05). Conclusion Intramuscular injection of BTX-A could reduce the sebum secretion of the region 0.5 cm far around the injection point and lead to the compensatory increase of sebum secretion on the region 1.6-2.5 cm far around injection point.