CAJ | 학술논문

婴幼儿血管瘤（IH）是最常见的儿童期良性肿瘤，具有独特的增生和自发消退的自然病程，但发病机制仍未阐明，血管瘤的标志物也缺乏特异性。目前，组织学标志物主要包括血管生成、胎盘、凋亡、缺氧、炎症、淋巴、干细胞、周细胞、肥大细胞等相关标志物；体液标志物包含血清和尿液标志物，前者主要有雌激素和VEGF等细胞因子，后者主要有bFGF和MMP-2。但至今尚未发现与IH病程密切相关、特异度敏感度较强的血清标志物，本文就此方面的研究进展进行综述。
영유인혈관류（IH）시최상견적인동기량성종류，구유독특적증생화자발소퇴적자연병정，단발병궤제잉미천명，혈관류적표지물야결핍특이성。목전，조직학표지물주요포괄혈관생성、태반、조망、결양、염증、림파、간세포、주세포、비대세포등상관표지물；체액표지물포함혈청화뇨액표지물，전자주요유자격소화VEGF등세포인자，후자주요유bFGF화MMP-2。단지금상미발현여IH병정밀절상관、특이도민감도교강적혈청표지물，본문취차방면적연구진전진행종술。
Infantile hemangioma (IH) is the most common benign tumor in childhood, which has unique natural history with early proliferation and spontaneous involution courses. However its pathogenesis has not been elucidated, especially its specific biomarkers. In this paper, the research progress of this aspect was reviewed. Histologic biomarkers were consist of angiogenesis, placenta, apoptosis, hypoxia, inflammation, lymphatic, stem cell, pericyte and mast cell associated markers. Humoral biomarkers contained serum and urine markers, the former mainly had the cytokines such as estrogen and VEGF, the latter included bFGF and MMP-2. But so far there were not serum markers found to be closely related to the course of IH with strong sensitivity and specificity.