CAJ | 학술논문

背景右美托咪定(dexmedetomidine,Dex)是高选择性α2肾上腺素能受体激动剂,具有镇静、镇痛、降低交感神经张力等作用,同时无呼吸抑制及脑电干扰等副作用,现已广泛应用于重症监护病房(ICU)及围术期辅助镇静.近期研究发现Dex具有心脏保护作用,如抗缺血/再灌注损伤(ischemia/repeffusion injury,I/RI)、抗心律失常等. 目的对Dex心脏保护作用的研究进展作一综述,为其合理应用提供参考. 内容介绍Dex对心脏的保护作用及其相关机制. 趋向深入研究Dex心脏保护作用及其机制有望改善相关患者的预后.
배경 우미탁미정(dexmedetomidine,Dex)시고선택성α2신상선소능수체격동제,구유진정、진통、강저교감신경장력등작용,동시무호흡억제급뇌전간우등부작용,현이엄범응용우중증감호병방(ICU)급위술기보조진정.근기연구발현Dex구유심장보호작용,여항결혈/재관주손상(ischemia/repeffusion injury,I/RI)、항심률실상등. 목적 대Dex심장보호작용적연구진전작일종술,위기합리응용제공삼고. 내용 개소Dex대심장적보호작용급기상관궤제. 추향 심입연구Dex심장보호작용급기궤제유망개선상관환자적예후.
Background Dexmedetomidine(Dex) is a α2 adrenergic receptor agonist used with increasing frequency in both the intensive care unit (ICU) and the operating room,which exhibits sedation,analgesia,anti-anxiety,sympatholytic effects and so on.Meanwhile,it has low side-effects including respiratory depression and brain electrical interference.Recent evidence from animals and clinical studies shows that Dex has cardioprotective effects,such as anti-ischemia/reperfusion injury (I/RI) and antiarrhythmia.Objective This review discusses the cardioprotective effects for Dex in order to provide a reference for its suitable application.Content This paper reviews the cardioprotective effects of Dex together with the possible mechanisms.Trend More studies are needed to reveal the mechanisms of the cardioprotective effects of Dex,which may improve patients' prognosis.