CAJ | 학술논문

目的：研究蛇床子素（osthol，Ost）在大鼠体内的组织分布特征，为临床合理用药提供合理依据。方法：大鼠腹腔注射（intraperitoneal injection，ip）30，120 mg·kg-1蛇床子素后，采用RP-HPLC法测定大鼠组织中不同时间点的药物浓度，分析蛇床子素在大鼠体内的组织分布特点。结果：大鼠腹腔注射蛇床子素后，组织分布较快，给药5 min 8种组织中均可检测到蛇床子素，10 min内心、肝、肺、肾均可达到峰值。当给药浓度增加4倍时，蛇床子素在各组织中的达峰时间没有显著性变化，只是相应时间点的药物浓度均略有升高，药物消除的时间也相应延长。结论：蛇床子素在大鼠组织中分布快、广泛，消除也快，且可能穿越血脑屏障和血睾屏障。
목적：연구사상자소（osthol，Ost）재대서체내적조직분포특정，위림상합리용약제공합리의거。방법：대서복강주사（intraperitoneal injection，ip）30，120 mg·kg-1사상자소후，채용RP-HPLC법측정대서조직중불동시간점적약물농도，분석사상자소재대서체내적조직분포특점。결과：대서복강주사사상자소후，조직분포교쾌，급약5 min 8충조직중균가검측도사상자소，10 min내심、간、폐、신균가체도봉치。당급약농도증가4배시，사상자소재각조직중적체봉시간몰유현저성변화，지시상응시간점적약물농도균략유승고，약물소제적시간야상응연장。결론：사상자소재대서조직중분포쾌、엄범，소제야쾌，차가능천월혈뇌병장화혈고병장。
Objective:To study the tissue distribution of osthol on rats and to provide bases for clinical applications. Methods:After osthol was administered to rats(30,120 mg·kg-1 ip),the concentration of osthol in rat tissues after different time was determined by RP-HPLC. Results:Osthol distributed rapidly in the tissues after ip:eight tissues can detected osthol after 5 min. Heart,liver, lung and kidney all reached Cmax in 10 min. When the dose is increased 4 folds,Tpeaks of osthol in tissues had no significant changes,except the concentration and elimination time increased slightly corresponding to the same time-point. Conclusion:Osthol was distributed rapidly and extensively in the rat’s body and may pass through blood-brain-barrier and blood-testis-barrier.