神经药理学报
神經藥理學報
신경약이학보
Journal of Hebei North University(Medical Edition)
2014年
1期
58-64
,共7页
MKP-1%MAPKs%去磷酸化%转录%突触可塑性%抑郁%神经炎症
MKP-1%MAPKs%去燐痠化%轉錄%突觸可塑性%抑鬱%神經炎癥
MKP-1%MAPKs%거린산화%전록%돌촉가소성%억욱%신경염증
MKP-1%MAPKs%dephosporylation%transcription%synaptic plasticity%drepression%neuroinflammation
丝裂原活化蛋白激酶磷酸酶-1（mitogen-activated protein kinase phosphatase-1，MKP-1）作为生物体内重要的信号转导系统-丝裂原活化蛋白激酶系统（mitogen-activated protein kinases，MAPKs）去磷酸化的重要调节者，在包括神经系统的各种生物学系统中发挥重要作用。该文对MKP-1的生物学活性、调控以及在神经系统中的作用进行综述，以期为MKP-1作为药理学靶点的相关研究提供参考。
絲裂原活化蛋白激酶燐痠酶-1（mitogen-activated protein kinase phosphatase-1，MKP-1）作為生物體內重要的信號轉導繫統-絲裂原活化蛋白激酶繫統（mitogen-activated protein kinases，MAPKs）去燐痠化的重要調節者，在包括神經繫統的各種生物學繫統中髮揮重要作用。該文對MKP-1的生物學活性、調控以及在神經繫統中的作用進行綜述，以期為MKP-1作為藥理學靶點的相關研究提供參攷。
사렬원활화단백격매린산매-1（mitogen-activated protein kinase phosphatase-1，MKP-1）작위생물체내중요적신호전도계통-사렬원활화단백격매계통（mitogen-activated protein kinases，MAPKs）거린산화적중요조절자，재포괄신경계통적각충생물학계통중발휘중요작용。해문대MKP-1적생물학활성、조공이급재신경계통중적작용진행종술，이기위MKP-1작위약이학파점적상관연구제공삼고。
As a major regulator of dephosphorylation of mitogen-activated protein kinases (MAPKs)which are important signal transduction pathways in organisms, mitogen-activated protein kinase phosphatase-1(MKP-1)plays a crucial role in various biological systems, including nervous system. This paper summarized the biological activity, regulation, new results and progress of MKP-1 in recent years, with a focus on the central nervous system. We proposed that MKP-1 is a drug target for future pharmacological research.
