CAJ | 학술논문

对抑郁症发病机制的解释主要以中枢神经系统单胺类递质的功能失调为主，然而新的研究表明除单胺类神经递质外，谷氨酸等神经递质也扮演了非常重要的角色。该文就谷氨酸循环的生理特点及其在抑郁症中可能的病理生理作用及各类针对谷氨酸异常抗抑郁药物的治疗进展进行综述。
대억욱증발병궤제적해석주요이중추신경계통단알류체질적공능실조위주，연이신적연구표명제단알류신경체질외，곡안산등신경체질야분연료비상중요적각색。해문취곡안산순배적생리특점급기재억욱증중가능적병리생리작용급각류침대곡안산이상항억욱약물적치료진전진행종술。
The“monoamine hypothesis”of depression,which posits that depression is caused by decreased monoamine function in the brain,originated several decades ago. Although these monoamine-based agents are potent antidepressants,the cause of depression is far from being a simple deficiency of central monoamines. The glutamatergic system also plays important roles in the pathophysiology of major depressive disorder. This paper summarized the physiological characteristics of glutamate in the brain,glutamatergic abnormalities in depression and antidepressants acting on the glutamatergic system.