CAJ | 학술논문

综述了丹酚酸B（salvianolic acid B，Sal B）对β-淀粉样蛋白（amyloidβ-protein，Aβ）、tau蛋白毒性及两者引起的PC-12细胞和SH-SY5Y细胞凋亡的作用，及其对神经发生、血管生成的影响。Sal B能抑制Aβ的原纤维成形、聚集，降低Aβ毒性并减少其引起的细胞凋亡；抑制tau蛋白的过度磷酸化；促进神经发生和血管生成。基于Sal B对神经系统的保护作用，故其可能作为治疗神经退行性疾病的潜在药物。
종술료단분산B（salvianolic acid B，Sal B）대β-정분양단백（amyloidβ-protein，Aβ）、tau단백독성급량자인기적PC-12세포화SH-SY5Y세포조망적작용，급기대신경발생、혈관생성적영향。Sal B능억제Aβ적원섬유성형、취집，강저Aβ독성병감소기인기적세포조망；억제tau단백적과도린산화；촉진신경발생화혈관생성。기우Sal B대신경계통적보호작용，고기가능작위치료신경퇴행성질병적잠재약물。
This paper reviewed the effect of salvianolic acid B(Sal B)on toxicity of amyloidβ-protein(Aβ),tau protein and PC-12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein,and on neurogenesis and angiogenesis. The results showed that Sal B could decrease the toxicity of Aβby inhibiting Aβaggregation and fibril formation,and protect cells damaged by Aβ. Hyperphosphorylation of tau protein could be attenuated by Sal B. Sal B has also been proved to promote neurogenesis and angiogenesis. Based on the neuroprotective effect of Sal B,it may be a potential medicine for treatment of neurodegenerative disease.