CAJ | 학술논문

目的：探讨米诺环素辅助治疗精神分裂症阴性症状的效果及免疫学机制。方法将92例符合美国《精神疾病诊断与统计手册(第4版)》(DSM- IV)诊断标准、以阴性症状为主且单一利培酮治疗的精神分裂症患者随机分为米诺环素组(n=46)或安慰剂对照组(n=46)，治疗周期为16周。于入组及出组时以阴性症状评定量表(SANS)、阳性和阴性症状量表(PANSS)评定疗效，测定治疗前后白介素1-β(IL-1β)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)浓度变化。结果 PANSS阴性症状评分和总评分与安慰剂组相比，减分差异有统计学意义(P<0.01)；两组治疗前后除 NO 外其余两个因子的浓度变化均无统计学意义(P>0.05)。结论米诺环素辅助治疗精神分裂症的阴性症状有效，但作用机制仍不明，是否通过抑制 NO 浓度的变化尚需进一步的研究。
목적：탐토미낙배소보조치료정신분렬증음성증상적효과급면역학궤제。방법장92례부합미국《정신질병진단여통계수책(제4판)》(DSM- IV)진단표준、이음성증상위주차단일리배동치료적정신분렬증환자수궤분위미낙배소조(n=46)혹안위제대조조(n=46)，치료주기위16주。우입조급출조시이음성증상평정량표(SANS)、양성화음성증상량표(PANSS)평정료효，측정치료전후백개소1-β(IL-1β)、종류배사인자-α(TNF-α)、일양화담(NO)농도변화。결과 PANSS음성증상평분화총평분여안위제조상비，감분차이유통계학의의(P<0.01)；량조치료전후제 NO 외기여량개인자적농도변화균무통계학의의(P>0.05)。결론미낙배소보조치료정신분렬증적음성증상유효，단작용궤제잉불명，시부통과억제 NO 농도적변화상수진일보적연구。
Objective Our study explore the efficacy and mechanism of minocycline combining with risperidone in the treat-ment of negative symptom in early-phase schizophrenia.Methods Ninety-two patients with early stage schizophrenia treated with risperidone were randomly assigned to receive minocycline or placebo.Two treatment group both take 1 6-weeks.The clinical effectand immune factor were assessed with the Scale for the Assessment of Negative Symptoms (SANS),the Positive and Negative Syndrome Scale (PANSS),concentration of IL-1β,TNF-α,NObefore the treatment and the end.Results Sub-jects receiving minocycline had greater improvements on PANSS negative subscale scores and PANSS total score (P<0.01) when compared with those receiving placebo.Minocycline have no effect on the concentration of IL-1β,TNF-αexcept for NO.Conclusion The addition of minocycline to atypical antipsychoticdrugs in early schizophrenia had significant efficacy on neg-ative symptoms.The mechanism is still unknown and is speculated to be related to inhibited the concentration of NO.