CAJ | 학술논문

对于痢疾、伤寒、副伤寒和霍乱等肠道致病菌引起的肠道传染性疾病，其感染途径相同，感染机制相似，均能诱发肠道局部黏膜免疫反应。预防上述几种传染性疾病的疫苗，传统的评价方法是分析其肠黏膜分泌型IgA抗体水平。随着对上述几种肠道传染性疾病免疫学机制以及对感染者血清抗体水平与其肠黏膜抗体水平之间关系的深入研究，评价疫苗效力的方法逐渐改为测定血清抗体。对上述几种传染性疾病的感染机制以及血清学评价方法进行了综述。
대우이질、상한、부상한화곽란등장도치병균인기적장도전염성질병，기감염도경상동，감염궤제상사，균능유발장도국부점막면역반응。예방상술궤충전염성질병적역묘，전통적평개방법시분석기장점막분비형IgA항체수평。수착대상술궤충장도전염성질병면역학궤제이급대감염자혈청항체수평여기장점막항체수평지간관계적심입연구，평개역묘효력적방법축점개위측정혈청항체。대상술궤충전염성질병적감염궤제이급혈청학평개방법진행료종술。
The infection mechanism of dysentery, typhoid, paratyphoid and cholera is similar. They can all induce intesti-nal mucosal immune response. Analysing the mucosal immune antibody level is the traditional evaluation method of these vaccines. However, with the in-depth study of the infection mechanism and the study on the relationship between the muco-sal immune antibody level and serum immune antibody level, people evaluate the effectiveness of corresponding vaccine through determining serum antibody. In this paper, the mechanism of infection of the diseases above and serological evalua-tion methods were reviewed.