CAJ | 학술논문

研究证明，脑膜炎球菌荚膜多糖、多糖蛋白结合物以及外膜蛋白等物质都能够诱导产生抗体，帮助保护机体抵御脑膜炎球菌疾病。阐述了脑膜炎球菌疫苗研制过程中特异性抗体的检测方法以及在疫苗效果评价中的意义，指出在脑膜炎球菌疫苗的效果评价中，抗体含量以及功能性抗体活性的检测是重要指标，为疫苗的市场应用提供了依据。
연구증명，뇌막염구균협막다당、다당단백결합물이급외막단백등물질도능구유도산생항체，방조보호궤체저어뇌막염구균질병。천술료뇌막염구균역묘연제과정중특이성항체적검측방법이급재역묘효과평개중적의의，지출재뇌막염구균역묘적효과평개중，항체함량이급공능성항체활성적검측시중요지표，위역묘적시장응용제공료의거。
It has been demonstrated that antibodies induced by Meningococcal polysaccharide, polysaccharide-protein con-jugate and outer-membrane protein vaccines can provide the protection against meningitis disease. This review will describe main methods of the specific antibody detection and related progress. In the process of the efficacy evaluation of Meningo-coccal vaccine, antibodies concentration and functional antibody activity are critical indicators for vaccine efficacy, and these researches will provide strong evidence for new Meningococcal vaccine candidates.