CAJ | 학술논문

黄病毒属病毒是单股正链RNA病毒，病毒基因组编码至少三种结构蛋白(衣壳蛋白C、膜蛋白M和包膜蛋白E)和七种非结构蛋白。其中E蛋白是病毒的重要抗原成分，包含有中和抗原表位和型特异性抗原表位，决定了病毒的细胞嗜性和毒力，与病毒的吸附、穿入、致病等作用密切相关，并且具有血凝活性，能刺激机体产生中和抗体和血凝抑制抗体。研究E蛋白的结构与功能对于深入了解黄病毒致病机制和免疫应答特点，研发疫苗和特异性抗病毒药物均有重要的指导意义。为此，综述了近年来黄病毒E蛋白有关结构与功能的研究进展及其生物学意义。
황병독속병독시단고정련RNA병독，병독기인조편마지소삼충결구단백(의각단백C、막단백M화포막단백E)화칠충비결구단백。기중E단백시병독적중요항원성분，포함유중화항원표위화형특이성항원표위，결정료병독적세포기성화독력，여병독적흡부、천입、치병등작용밀절상관，병차구유혈응활성，능자격궤체산생중화항체화혈응억제항체。연구E단백적결구여공능대우심입료해황병독치병궤제화면역응답특점，연발역묘화특이성항병독약물균유중요적지도의의。위차，종술료근년래황병독E단백유관결구여공능적연구진전급기생물학의의。
The Flaviviruses are single-stranded positive-sense RNA encoding at least three structural proteins and seven non-structural proteins. As the major antigen of flaviviruses, the envelope ( E) glycoprotein is involved in various biological events,such as virus attachment, fusion, penetration, hemogglutination, host range and cell tropism. The flavivirus E pro-tein contains epitopes critical for eliciting neutralizing antibodies and hemogglutination inhibition antibodies against the viru-ses. Therefore the study on the structure and function of E protein will provide useful information for further understanding molecular mechanism of pathogenicity and feature of immune responses of flaviviruses as well as developing vaccines and an-ti-viral drugs. This short review will focus on the recent advancement of the structure and function of flavivirus E protein and its biological significance.