汉坦病毒感染对Ⅰ型干扰素应答的调节机制
한탄병독감염대Ⅰ형간우소응답적조절궤제
Regulation of type I interferon in the process of hantavirus infection
  • 万方数据
    微生物学免疫学进展 미생물학면역학진전
    PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY
    2014年 3期 44-48 ,共5页

    徐永妮%曹梦远(综述)%叶伟%张芳琳(审校)

    서영니%조몽원(종술)%협위%장방림(심교)

    汉坦病毒%Ⅰ型干扰素%调节机制 漢坦病毒%Ⅰ型榦擾素%調節機製
    한탄병독%Ⅰ형간우소%조절궤제
    Hantavirus (HTNV)%Type I interferon%Regulation mechanism
    汉坦病毒主要感染人内皮细胞，细胞在病毒感染早期诱导生成的Ⅰ型干扰素( IFN-Ⅰ)可阻断汉坦病毒的复制，但不同的病毒蛋白和不同型别的汉坦病毒在IFN应答的调节机制上可能有所不同。就汉坦病毒感染对IFN应答的调节机制进行了综述。
    한탄병독주요감염인내피세포，세포재병독감염조기유도생성적Ⅰ형간우소( IFN-Ⅰ)가조단한탄병독적복제，단불동적병독단백화불동형별적한탄병독재IFN응답적조절궤제상가능유소불동。취한탄병독감염대IFN응답적조절궤제진행료종술。
    Hantaviruses primarily infect human vascular endothelial cells ( VECs) , and type I interferon ( IFN) which is induced by Hantavirus infection in early phase can block the replication of Hantavirus, but the different viral proteins and different types of Hantavirus may play the different role in the regulation of IFN response. This paper reviews the regulation mechanism of IFN responses by Hantavirus infection.
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