CAJ | 학술논문

目的：评估宫颈液基细胞学结合高危性HPV DNA检测在宫颈病变中的诊断价值。方法收集本院2009-2012年细胞室及HPV检测室的资料进行评估分析。结果液基细胞学阳性检出率6.01%，HPVDNA高危型分型检出率20.34%，两种方法联合检测的评估指标：阳性检测率33%，敏感性、特异性、阳性预测值、阴性预测值88.58%。结论单独应用上述两种筛查方法都有一定的局限性，但有较高敏感性，阴性预测值及阳性检出率。联合应用检测后不但能够优势互补，而且其敏感性、阴性预测值、阳性检出率更高，但其特异性反而降低。具体原因不详，有待于在今后工作中进一步深入探讨。对已婚妇女在进行细胞学及HPV检测的同时，对HPV检测阳性病例如能采用HPV疫苗治疗，对于HPV检测阴性病例如能早期接种HPV疫苗预防，对于宫颈癌的防治效果会更加科学与完善。
목적：평고궁경액기세포학결합고위성HPV DNA검측재궁경병변중적진단개치。방법수집본원2009-2012년세포실급HPV검측실적자료진행평고분석。결과액기세포학양성검출솔6.01%，HPVDNA고위형분형검출솔20.34%，량충방법연합검측적평고지표：양성검측솔33%，민감성、특이성、양성예측치、음성예측치88.58%。결론단독응용상술량충사사방법도유일정적국한성，단유교고민감성，음성예측치급양성검출솔。연합응용검측후불단능구우세호보，이차기민감성、음성예측치、양성검출솔경고，단기특이성반이강저。구체원인불상，유대우재금후공작중진일보심입탐토。대이혼부녀재진행세포학급HPV검측적동시，대HPV검측양성병례여능채용HPV역묘치료，대우HPV검측음성병례여능조기접충HPV역묘예방，대우궁경암적방치효과회경가과학여완선。
Objective To evaluate the diagnostic value of liquid-based cytologic test combined with high-risk HPV DNA de-tection in the diagnosis of cervical lesions. Methods The data of HPV and liquid-based cytologic test derived from the cell apart-ment and HPV test room in Xiaolan hospital from 2009 to 2012 were collected, evaluated and analyzed. Results The positive de-tection rate of liquid-based cytologic test was 6.01%. The positive rate of high-risk HPV DNA detection was 20.34%. The perfor-mance of the combination method was as follows: the positive detection rate was 33%; the sensitivity was 96.43%; the specificity was 12.62%;the positive predictive rate was 33.49%;the negative predictive rate was 88.58%. Conclusions There exist some cer-tain limitations when using LCT or HPV DNA test along. The two methods shoud be used together. The combination method had a higher sensitivity, negative predictive rate and positive detection rate, but the specificity was lower than that of each single method. HPV vaccine should be used rationally for early prevention of cervical carcinoma.