CAJ | 학술논문

目的：探讨结直肠癌组织Pokemon和c-myc蛋白表达的变化和意义。方法：SP免疫组化法检测60例结直肠癌组织和癌旁正常组织Pokemon和c-myc蛋白的表达情况。结果：结直肠癌组织Pokemon和c-myc蛋白的阳性表达率均明显高于正常组织(P＜0.01)；结直肠癌组织Pokemon和c-myc蛋白的阳性表达与分化程度、Dukes分期和淋巴结转移有关(P＜0.01，P＜0.05)；结直肠癌组织中，Pokemon和c-myc蛋白的表达呈显著正相关(r=0.615，P＜0.05)。结论：Pokemon和c-myc对结直肠癌的诊断和预后评判具有一定的价值。
목적：탐토결직장암조직Pokemon화c-myc단백표체적변화화의의。방법：SP면역조화법검측60례결직장암조직화암방정상조직Pokemon화c-myc단백적표체정황。결과：결직장암조직Pokemon화c-myc단백적양성표체솔균명현고우정상조직(P＜0.01)；결직장암조직Pokemon화c-myc단백적양성표체여분화정도、Dukes분기화림파결전이유관(P＜0.01，P＜0.05)；결직장암조직중，Pokemon화c-myc단백적표체정현저정상관(r=0.615，P＜0.05)。결론：Pokemon화c-myc대결직장암적진단화예후평판구유일정적개치。
Objective: To investigate the expression and clinical significance of Pokemon and c-myc in human colorectal cancer.Methods: SP immunohistochemical staining was used to detect the expression of Pokemon and c-myc in 60 cases colorectal cancer and matched para-carcinoma tissues.Results:The positive expression rate of Pokemon and c-myc in colorectal cancer were obviously higher than that in normal tissue (P<0.01). In colorectal cancer, the positive expression of Pokemon and c-myc were related with differentiation degree, Dukes stage and lymph node metastasis (P<0.01,P<0.05). The positive expression of Pokemon in colorectal cancer was positively correlated with c-myc expression (r=0.615,P<0.05). Conclusions: Pokemon and c-myc have certain value for diagnosing and prognosis of colorectal cancer.