CAJ | 학술논문

目的：探讨Cx43、Smad1蛋白在胃癌中的表达及意义。方法：采用免疫组织化学染色法检测Cx43和Smad1在胃癌和癌旁组织中的表达情况。结果：胃癌组织Cx43的阳性表达率明显低于正常胃组织，Smad1的阳性表达率明显高于正常胃组织(P＜0.05)。胃癌组织Smad1、Cx43蛋白的表达与年龄、性别无关，与分化程度、淋巴结转移和浸润深度有关(P＜0.01，P＜0.05)。胃癌组织Cx43与Smad1的表达呈显著负相关(P＜0.01)。结论：Cx43、Smad1蛋白的异常表达可能在胃癌的发生发展中具有重要作用。
목적：탐토Cx43、Smad1단백재위암중적표체급의의。방법：채용면역조직화학염색법검측Cx43화Smad1재위암화암방조직중적표체정황。결과：위암조직Cx43적양성표체솔명현저우정상위조직，Smad1적양성표체솔명현고우정상위조직(P＜0.05)。위암조직Smad1、Cx43단백적표체여년령、성별무관，여분화정도、림파결전이화침윤심도유관(P＜0.01，P＜0.05)。위암조직Cx43여Smad1적표체정현저부상관(P＜0.01)。결론：Cx43、Smad1단백적이상표체가능재위암적발생발전중구유중요작용。
Objective: To investigate the expression and clinical signiifcance of Cx43 and Smad1 in gastric cancer. Methods: Immunohistochemical staining was used to detect the expression of Cx43 and Smad1 in gastric cancer and para-carcinoma tissue.Results: The positive expression rate of Cx43 in gastric cancer was obviously lower than normal gastric tissue, while the positive rate of Smad1 was obviously higher (P<0.05). In gastric cancer, the positive expression of Cx43 and Smad1 were irrelevant to age and sex, but associated with differentiation degree, lymph node metastasis and invasion depth (P<0.01,P<0.05). In gastric cancer, the expression of Cx43 showed signiifcant negative correlation with Smad1 expression(P<0.01).Conclusions:Abnormal expression of Cx43 and Smad1 may play important role in development of gastric cancer.