CAJ | 학술논문

目的：测定KK/Upj-Ay/J小鼠的主要脏器重量，血液生理生化指标。方法选取5周龄和10周龄的KK/Upj-Ay/J小鼠，测定主要脏器重量和血液生理生化指标。结果不同周龄和性别的KK/Upj-Ay/J小鼠部分脏器重量和血生理生化有差异性。 KK/Upj-Ay/J小鼠禁食血糖值在10周龄时达到7.0 mmol/L以上。结论周龄和性别对KK/Upj-Ay/J小鼠的脏器重量和血生理生化值有影响。 KK/Upj-Ay/J小鼠在10周龄左右空腹血糖值达到糖尿病发病水平，是可用于Ⅱ型糖尿病研究的自发型动物模型。
목적：측정KK/Upj-Ay/J소서적주요장기중량，혈액생리생화지표。방법선취5주령화10주령적KK/Upj-Ay/J소서，측정주요장기중량화혈액생리생화지표。결과불동주령화성별적KK/Upj-Ay/J소서부분장기중량화혈생리생화유차이성。 KK/Upj-Ay/J소서금식혈당치재10주령시체도7.0 mmol/L이상。결론주령화성별대KK/Upj-Ay/J소서적장기중량화혈생리생화치유영향。 KK/Upj-Ay/J소서재10주령좌우공복혈당치체도당뇨병발병수평，시가용우Ⅱ형당뇨병연구적자발형동물모형。
Objective To measure the organ weights , blood physiological and biochemical parameters of KK /Upj-Ay/J.Methods KK/Upj-Ay/J mice at five and ten weeks of age were selected , and the organ weights , blood physiological and biochemical parameters were observed .Results Parts of the organ weights , blood physiological and biochemical parameters of different ages and sexes were significant differences .The fasted blood glucose of KK/Upj-Ay/J mice reached 7.0mmol/L at 10 weeks of age .Conclusion The results show that the organ weights , blood physiological and biochemical parameters are affected by age and gender of KK /Upj-Ay/J mice.The fasted blood glucose reached the diabetes level at 10 weeks of age .