CAJ | 학술논문

目的：探讨阿托伐他汀对颈内动脉粥样斑块及脑梗死复发的影响。方法对236例急性脑梗死患者根据治疗方法分为观察组（143例）及对照组（93例），并通过颈部血管B超检查比较2组患者治疗前及治疗后1年的颈内动脉内中膜厚度（IMT）及斑块稳定性；比较2组患者治疗后1年的的脑梗死复发情况。结果2组患者治疗前IMT及斑块稳定性比较差异均无统计学意义（均P＞0．05）；治疗1年后与对照组比较，观察组 IMT降低，稳定斑块患者数增加（均P＜0．05）；治疗1年后观察组脑梗死复发率明显低于对照组（P＜0．05）。结论阿托伐他汀能稳定并逆转粥样硬化斑块，影响动脉粥样硬化进程，能有效降低脑梗死的复发。
목적：탐토아탁벌타정대경내동맥죽양반괴급뇌경사복발적영향。방법대236례급성뇌경사환자근거치료방법분위관찰조（143례）급대조조（93례），병통과경부혈관B초검사비교2조환자치료전급치료후1년적경내동맥내중막후도（IMT）급반괴은정성；비교2조환자치료후1년적적뇌경사복발정황。결과2조환자치료전IMT급반괴은정성비교차이균무통계학의의（균P＞0．05）；치료1년후여대조조비교，관찰조 IMT강저，은정반괴환자수증가（균P＜0．05）；치료1년후관찰조뇌경사복발솔명현저우대조조（P＜0．05）。결론아탁벌타정능은정병역전죽양경화반괴，영향동맥죽양경화진정，능유효강저뇌경사적복발。
Objective To investigate the effects of atorvastatin on internal carotid artery ather-osclerosis and recurrence of cerebral infarction.Methods A total of 236 patients with acute cere-bral infarction were divided into observation group(n=143)and control group(n=93).Carotid intima-media thickness (IMT)and plaque stability were detected by vascular ultrasound before and 1 year after treatment.The recurrence of cerebral infarction was compared between the two groups.Results There were no significant differences in IMT and plaque stability between the two groups before treatment(P>0.05).Compared with control group,observation group had a decrease in the IMT,an increase in the number of stable plaques and a reduction in the recurrence rate of cerebral infarction 1 year after treatment(P<0.05).Conclusion Atorvastatin treatment can stabilize and retrieve atherosclerotic plaques,retard atherosclerosis development,and reduce recurrence of cerebral infarction.