南昌大学学报(医学版)
南昌大學學報(醫學版)
남창대학학보(의학판)
ACTA ACADEMIAE MEDICINAE JIANGXI
2014年
4期
31-33,37
,共4页
曾春平%陈幼萍%杨清水%廖信芳%曾龙驿
曾春平%陳幼萍%楊清水%廖信芳%曾龍驛
증춘평%진유평%양청수%료신방%증룡역
胰岛素抵抗%结直肠癌%风险%危险因素
胰島素牴抗%結直腸癌%風險%危險因素
이도소저항%결직장암%풍험%위험인소
insulin resistance%colorectal cancer%risk%risk factor
目的:探讨胰岛素抵抗与结直肠癌患病的关系。方法以新诊断的126例结直肠癌(CRC)患者为病例组(CRC组),以同期体检的137例健康人群作为对照组。比较2组人群空腹及餐后2 h血糖、胰岛素及胰岛素抵抗指数水平间的差异,并对CRC患者的患病进行多因素分析。结果 CRC组的空腹胰岛素水平、餐后胰岛素水平和胰岛素抵抗指数均高于对照组(P<0.05),而 FPG及 PPG 2组间比较差异无统计学意义(P>0.05);多因素回归分析显示年龄、性别、糖尿病家族史及饮酒未进入方程,对结直肠癌未见显著影响;胰岛素抵抗对结直肠癌患病具有显著影响。结论胰岛素抵抗可能会增加罹患结直肠癌的风险,是结直肠癌患病的危险因素。
目的:探討胰島素牴抗與結直腸癌患病的關繫。方法以新診斷的126例結直腸癌(CRC)患者為病例組(CRC組),以同期體檢的137例健康人群作為對照組。比較2組人群空腹及餐後2 h血糖、胰島素及胰島素牴抗指數水平間的差異,併對CRC患者的患病進行多因素分析。結果 CRC組的空腹胰島素水平、餐後胰島素水平和胰島素牴抗指數均高于對照組(P<0.05),而 FPG及 PPG 2組間比較差異無統計學意義(P>0.05);多因素迴歸分析顯示年齡、性彆、糖尿病傢族史及飲酒未進入方程,對結直腸癌未見顯著影響;胰島素牴抗對結直腸癌患病具有顯著影響。結論胰島素牴抗可能會增加罹患結直腸癌的風險,是結直腸癌患病的危險因素。
목적:탐토이도소저항여결직장암환병적관계。방법이신진단적126례결직장암(CRC)환자위병례조(CRC조),이동기체검적137례건강인군작위대조조。비교2조인군공복급찬후2 h혈당、이도소급이도소저항지수수평간적차이,병대CRC환자적환병진행다인소분석。결과 CRC조적공복이도소수평、찬후이도소수평화이도소저항지수균고우대조조(P<0.05),이 FPG급 PPG 2조간비교차이무통계학의의(P>0.05);다인소회귀분석현시년령、성별、당뇨병가족사급음주미진입방정,대결직장암미견현저영향;이도소저항대결직장암환병구유현저영향。결론이도소저항가능회증가리환결직장암적풍험,시결직장암환병적위험인소。
Objective To investigate the relationship between insulin resistance and colorectal cancer (CRC).Methods Fasting and 2-hour postprandial blood glucose,insulin and insulin re-sistance indexes were compared between 126 patients with newly diagnosed CRC (CRC group) and 137 healthy subjects (control group).In addition,a multiple regression analysis was per-formed to assess the factors influencing CRC.Results Compared with control group,fasting ser-um insulin concentration,postprandial serum insulin concentration and resistance index signifi-cantly increased in CRC group (P<0.05).No significant differences in fasting and postprandial plasma glucose levels were found between the two groups (P>0.05).Multifactor regression a-nalysis showed that insulin resistance had a significant effect on CRC.However,the age,gender, drinking and family history of diabetes had no effects on CRC.Conclusion As an independent risk factor,insulin resistance may increase the risk of CRC.