CAJ | 학술논문

目的：测定超声引导下锁骨上臂丛神经阻滞罗哌卡因的半数有效浓度（EC50）。方法选择择期行手或前臂手术患者40例（ASAⅠ-Ⅱ级），采用超声引导下锁骨上臂从神经阻滞两点注射法注入罗哌卡因30 mL，罗哌卡因的浓度（质量百分比）分别由低到高设为0．15％、0．20％、0．25％、0．30％和0．35％，初始浓度0．25％，间隔浓度为0．05％，注药30 min后切皮时，视觉模拟评分（VAS）＞3分，改为全身麻醉下完成手术以及下一例采用高一级浓度。若 VAS≤3分，则下一例采用低一级浓度。采用 Probit法计算超声引导下锁骨上臂丛神经阻滞罗哌卡因的EC50及其95％可信区间（CI）。结果超声引导下罗哌卡因臂丛神经阻滞的 EC50为0．243％，其95％CI 为0．219％～0．266％。结论超声引导下罗哌卡因臂丛神经阻滞的 EC50为0．243％。
목적：측정초성인도하쇄골상비총신경조체라고잡인적반수유효농도（EC50）。방법선택택기행수혹전비수술환자40례（ASAⅠ-Ⅱ급），채용초성인도하쇄골상비종신경조체량점주사법주입라고잡인30 mL，라고잡인적농도（질량백분비）분별유저도고설위0．15％、0．20％、0．25％、0．30％화0．35％，초시농도0．25％，간격농도위0．05％，주약30 min후절피시，시각모의평분（VAS）＞3분，개위전신마취하완성수술이급하일례채용고일급농도。약 VAS≤3분，칙하일례채용저일급농도。채용 Probit법계산초성인도하쇄골상비총신경조체라고잡인적EC50급기95％가신구간（CI）。결과초성인도하라고잡인비총신경조체적 EC50위0．243％，기95％CI 위0．219％～0．266％。결론초성인도하라고잡인비총신경조체적 EC50위0．243％。
Objective To determine the median effective concentration(EC50)of ropivacaine for ultrasound-guided supraclavicular brachial plexus block.Methods Forty ASAⅠorⅡ patients scheduled for hand or forearm surgery were given double point injection with 30 mL ropivacaine for ultrasound-guided supraclavicular brachial plexus block.The ropivacaine was inj ected at con-centrations of 0.15%,0.20%,0.25%,0.30% and 0.35%.The initial concentration was 0.25%and the concentration interval was 0.05%.The anesthetic efficacy was assessed with visual ana-logue scale(VAS)30 minutes after ropivacaine injection.General anesthesia was performed in pa-tients with VAS score greater than 3 and the next case was given higher concentration of ropiva-caine.If VAS score was less than 3,the next case was given lower concentration of ropivacaine. The EC50 of ropivacaine for ultrasound-guided supraclavicular brachial plexus block and the 95%confidence interval were calculated using probit analysis.Results The EC50 of ropivacaine for ul-trasound-guided supraclavicular brachial plexus block was 0.243% and the 95% confidence inter-val ranged from 0.219% to 0.266%.Conclusion The EC50 of ropivacaine was 0.243% for ultra-sound-guided supraclavicular brachial plexus block.