南昌大学学报(医学版)
南昌大學學報(醫學版)
남창대학학보(의학판)
ACTA ACADEMIAE MEDICINAE JIANGXI
2014年
4期
9-13
,共5页
王静媛%陈阿梅%刘秀兰%康世荣
王靜媛%陳阿梅%劉秀蘭%康世榮
왕정원%진아매%류수란%강세영
胞浆磷脂酶A2%微粒体前列腺素E合成酶-1%肺癌%临床特征%病理特征
胞漿燐脂酶A2%微粒體前列腺素E閤成酶-1%肺癌%臨床特徵%病理特徵
포장린지매A2%미립체전렬선소E합성매-1%폐암%림상특정%병리특정
cytosolic phospholipase A2%microsomal prostaglandin E synthase-1%lung cancer%clinical features%pathological features
目的:探讨胞浆型磷脂酶 A2(cPLA2)、微粒体前列腺素 E合成酶-1(mPGES-1)在肺癌组织中的表达及临床意义,为肺癌发生发展的分子机制提供理论依据。方法采用 RT-PCR检测60例肺癌(肺癌组)和癌旁(癌旁组)组织中 cPLA2、mPGEs-1 mRNA表达水平,采用免疫组织化学 SP法检测2组组织中 cPLA2、mPGEs-1蛋白表达水平。结果肺癌组组织中 cPLA2、mPGES-1 mRNA表达水平均明显高于癌旁组(均P<0.05)。肺癌组组织中 cPLA2蛋白阳性表达率为76.7%(46/60),癌旁组组织中 cPLA2蛋白无阳性表达,2组比较差异有统计学意义(P<0.05);肺癌组组织中 mPGES-1蛋白阳性表达率为66.7%(40/60),明显高于癌旁组的10.0%(6/60)(P<0.05)。肺癌组的肿瘤<5 cm、组织学类型为鳞癌、病理分级为高中分化、淋巴结无转移和TNM分期为Ⅰ期cPLA2蛋白阳性表达率与肿瘤≥5 cm、组织学类型为腺癌、病理分级为低分化、淋巴结有转移和 TNM 分期为Ⅱ、Ⅲ期比较差异均无统计学意义(均P>0.05);肺癌组的肿瘤<5 cm、组织学类型为鳞癌 mPGEs-1蛋白阳性表达率与肿瘤≥5 cm、组织学类型为腺癌比较差异均无统计学意义(均P>0.05),肺癌组的病理分级为高中分化、淋巴结无转移和TNM 分期为Ⅰ期mPGEs-1蛋白阳性表达率均明显低于病理分级为低分化、淋巴结有转移和 TNM 分期为Ⅱ、Ⅲ期(均P<0.05)。结论 cPLA2、mPGES-1的高表达可能在肺癌的发生发展中起着重要作用,其可能为肺癌的早期诊断和为开发肺癌的靶向治疗提供一定的临床依据。
目的:探討胞漿型燐脂酶 A2(cPLA2)、微粒體前列腺素 E閤成酶-1(mPGES-1)在肺癌組織中的錶達及臨床意義,為肺癌髮生髮展的分子機製提供理論依據。方法採用 RT-PCR檢測60例肺癌(肺癌組)和癌徬(癌徬組)組織中 cPLA2、mPGEs-1 mRNA錶達水平,採用免疫組織化學 SP法檢測2組組織中 cPLA2、mPGEs-1蛋白錶達水平。結果肺癌組組織中 cPLA2、mPGES-1 mRNA錶達水平均明顯高于癌徬組(均P<0.05)。肺癌組組織中 cPLA2蛋白暘性錶達率為76.7%(46/60),癌徬組組織中 cPLA2蛋白無暘性錶達,2組比較差異有統計學意義(P<0.05);肺癌組組織中 mPGES-1蛋白暘性錶達率為66.7%(40/60),明顯高于癌徬組的10.0%(6/60)(P<0.05)。肺癌組的腫瘤<5 cm、組織學類型為鱗癌、病理分級為高中分化、淋巴結無轉移和TNM分期為Ⅰ期cPLA2蛋白暘性錶達率與腫瘤≥5 cm、組織學類型為腺癌、病理分級為低分化、淋巴結有轉移和 TNM 分期為Ⅱ、Ⅲ期比較差異均無統計學意義(均P>0.05);肺癌組的腫瘤<5 cm、組織學類型為鱗癌 mPGEs-1蛋白暘性錶達率與腫瘤≥5 cm、組織學類型為腺癌比較差異均無統計學意義(均P>0.05),肺癌組的病理分級為高中分化、淋巴結無轉移和TNM 分期為Ⅰ期mPGEs-1蛋白暘性錶達率均明顯低于病理分級為低分化、淋巴結有轉移和 TNM 分期為Ⅱ、Ⅲ期(均P<0.05)。結論 cPLA2、mPGES-1的高錶達可能在肺癌的髮生髮展中起著重要作用,其可能為肺癌的早期診斷和為開髮肺癌的靶嚮治療提供一定的臨床依據。
목적:탐토포장형린지매 A2(cPLA2)、미립체전렬선소 E합성매-1(mPGES-1)재폐암조직중적표체급림상의의,위폐암발생발전적분자궤제제공이론의거。방법채용 RT-PCR검측60례폐암(폐암조)화암방(암방조)조직중 cPLA2、mPGEs-1 mRNA표체수평,채용면역조직화학 SP법검측2조조직중 cPLA2、mPGEs-1단백표체수평。결과폐암조조직중 cPLA2、mPGES-1 mRNA표체수평균명현고우암방조(균P<0.05)。폐암조조직중 cPLA2단백양성표체솔위76.7%(46/60),암방조조직중 cPLA2단백무양성표체,2조비교차이유통계학의의(P<0.05);폐암조조직중 mPGES-1단백양성표체솔위66.7%(40/60),명현고우암방조적10.0%(6/60)(P<0.05)。폐암조적종류<5 cm、조직학류형위린암、병리분급위고중분화、림파결무전이화TNM분기위Ⅰ기cPLA2단백양성표체솔여종류≥5 cm、조직학류형위선암、병리분급위저분화、림파결유전이화 TNM 분기위Ⅱ、Ⅲ기비교차이균무통계학의의(균P>0.05);폐암조적종류<5 cm、조직학류형위린암 mPGEs-1단백양성표체솔여종류≥5 cm、조직학류형위선암비교차이균무통계학의의(균P>0.05),폐암조적병리분급위고중분화、림파결무전이화TNM 분기위Ⅰ기mPGEs-1단백양성표체솔균명현저우병리분급위저분화、림파결유전이화 TNM 분기위Ⅱ、Ⅲ기(균P<0.05)。결론 cPLA2、mPGES-1적고표체가능재폐암적발생발전중기착중요작용,기가능위폐암적조기진단화위개발폐암적파향치료제공일정적림상의거。
Objective To explore the expression and clinical significance of cytosolic phospho-lipase A2(cPLA2)and microsomal prostaglandin E synthase-1(mPGES-1)in lung cancer,and to provide a theoretical basis for the molecular mechanism of the development of lung cancer.Meth-ods The mRNA and protein expression of cPLA2 and mPGES-1 in cancer tissues and adj acent tissues was detected by RT-PCR and immunohistochemical method in 60 cases of lung cancer,re-spectively.Results The mRNA expression of cPLA2 and mPGES-1 in cancer tissues was signifi-cantly higher than that in adjacent tissues(P<0.05).Furthermore,the positive expression rates of cPLA2 and mPGES-1 in cancer tissues were significantly higher than those in adj acent tissues (76.7% vs 0.0% and 66.7% vs 10.0%,respectively;P<0.05).There were no significant differ-ences in the positive rate of cPLA2 protein expression between squamous cell carcinoma(tumor size<5 cm,well differentiation,TNM stage I,and no lymph node metastasis)and adenocarcinoma (tumor size≥5 cm,poor differentiation,TNM stage Ⅱ-Ⅲ,and lymph node metastasis )(P>0.05).In addition,there were no significant differences in the positive rate of mPGEs-protein ex-pression between squamous cell carcinoma with tumor size<5 cm and adenocarcinoma with tumor size≥5 cm(P>0.05).However,the positive rate of mPGEs-protein expression in well-differenti-ated stageⅠcarcinoma without lymph node metastasis was significantly lower than that in poor-differentiated stageⅡ-Ⅲcarcinoma with lymph node metastasis(P<0.05).Conclusion The high expression of cPLA2 and mPGES-1 may play an important role in the occurrence and development of lung cancer.The detection of cPLA2 and mPGES-1 expression may provide a clinical basis for the early diagnosis and targeted therapy of lung cancer.