CAJ | 학술논문

目的：探讨封闭抗体与淋巴细胞免疫疗法治疗习惯性流产的关系及疗效。方法选择100例封闭抗体阴性不明原因习惯性流产病例，其中60例（试验组）进行淋巴细胞免疫治疗，并于治疗后复查封闭抗体、T 细胞亚群和 IgG、IgM 含量的改变，另40例（对照组）采用常规方法保胎治疗，对比两组妊娠结局。结果试验组妊娠成功率为81.7%，对照组为37.5%，二者有统计学差异（P <0.01）。试验组封闭抗体阳性者妊娠成功率为90.3%，封闭抗体阴性者为33.3%，亦有统计学差异（P <0.01）。试验组 CD4+ T 细胞较治疗前下降，CD8+ T 细胞治疗后上升， CD4+/ CD8+下降，IgG 与 IgM 治疗后亦下降明显，以上各指标免疫治疗前后均有显著差异（P 均<0.05）。结论封闭抗体对妊娠结局有一定影响，封闭抗体阴性患者进行淋巴细胞免疫治疗，安全方便，疗效肯定，值得加强推广。
목적：탐토봉폐항체여림파세포면역요법치료습관성유산적관계급료효。방법선택100례봉폐항체음성불명원인습관성유산병례，기중60례（시험조）진행림파세포면역치료，병우치료후복사봉폐항체、T 세포아군화 IgG、IgM 함량적개변，령40례（대조조）채용상규방법보태치료，대비량조임신결국。결과시험조임신성공솔위81.7%，대조조위37.5%，이자유통계학차이（P <0.01）。시험조봉폐항체양성자임신성공솔위90.3%，봉폐항체음성자위33.3%，역유통계학차이（P <0.01）。시험조 CD4+ T 세포교치료전하강，CD8+ T 세포치료후상승， CD4+/ CD8+하강，IgG 여 IgM 치료후역하강명현，이상각지표면역치료전후균유현저차이（P 균<0.05）。결론봉폐항체대임신결국유일정영향，봉폐항체음성환자진행림파세포면역치료，안전방편，료효긍정，치득가강추엄。
ObJective:To investigate the relationship and effect of blocking antibody and lymphocytes immunotherapy in recurrent spontaneous abortion. Methods:Of one hundred blocking antibody-negative patients with unexplained recurrent spontaneous abortion(URSA),60 patients(trial group)were chosen and treated with immunotherapy,and the changes of subtypes of lymphocytes and IgG,IgM were observed after immunotherapy,40 patients(control group)were treated with routine tocolysis,and the results were compared between the two groups. Results:The pregnancy success rate of trial group was 81. 7% ,but the control group was 37. 5% ,and there was a significant difference between the two groups(P < 0. 01). The pregnancy success rate of blocking antibody - positive in the trial group was 90. 3% ,and that of blocking antibody-neg-ative was 33. 3% ,and there also was a significant difference between them(P < 0. 01). In the trial group,after immunother-apy the amount of CD4 + T cells was significantly lower;the amount of CD8 + T cells was significantly higher;the ratio of CD4 + T/ CD8 + T was significantly lower than that before immunotherapy;the levels of IgG and IgM were significantly low-er. There was significant difference in all indexes before and after the treatment(P < 0. 05,all). Conclusion:Blocking anti-body can influence the result of pregnancy. Lymphocytes immunotherapy is safe,convenient and effective for patients with blocking antibody-negative,and it is well worth popularizing.