农业科学与技术(英文版)
農業科學與技術(英文版)
농업과학여기술(영문판)
AGRICULTURAL SCIENCE & TECHNOLOGY
2014年
5期
769-773,816
,共6页
王平%孟志远%陈思%陈小军
王平%孟誌遠%陳思%陳小軍
왕평%맹지원%진사%진소군
光敏剂%单线态氧%光活化毒杀作用%斜纹夜蛾细胞
光敏劑%單線態氧%光活化毒殺作用%斜紋夜蛾細胞
광민제%단선태양%광활화독살작용%사문야아세포
Photosensitizer%Singlet oxygen%Photoactivated activity%Spodoptera litura cel
[目的]提高光敏剂的光稳定性,延长光敏剂在环境中的半衰期。[方法]该研究以典型光敏剂α-三联噻吩为模板,利用生物等排原理,以苯环代替噻吩环,合成了光敏剂2,5-二苯基噻吩和2,5-二乙炔苯基噻吩,并研究了所合成的光敏剂的对斜纹夜蛾细胞的光活化毒力、单线态氧及光稳定性。[结果]光敏剂2,5-二苯基噻吩对斜纹夜蛾细胞的24和48 h的抑制中浓度IC50值分别为0.22和0.16μg/ml,2,5-二乙炔苯基噻吩斜纹夜蛾细胞的24和48 h的抑制中浓度 IC50值分别为0.06和0.04μg/ml;在紫外光照下,光敏剂2,5-二苯基噻吩和2,5-二乙炔苯基噻吩产生的1O2能力分别为1.0475和1.5294μg/mmol;2,5-二苯基噻吩和2,5-二乙炔苯基噻吩在甲醇中降解动力学方程分别为 Ct=5.2271e-0.061t和 Ct=5.0842e-0.0973t,其半衰期分别为111.79和7.12 h。[结论]所合成的光敏剂2,5-二苯基噻吩具有良好的光活化激发产生单线态氧的能力,对斜纹夜蛾SL细胞具有良好的光活化毒杀作用,克服了光活化杀虫剂见光易分解等不足,因此2,5-二苯基噻吩具有开发成光活化杀虫剂的潜力。
[目的]提高光敏劑的光穩定性,延長光敏劑在環境中的半衰期。[方法]該研究以典型光敏劑α-三聯噻吩為模闆,利用生物等排原理,以苯環代替噻吩環,閤成瞭光敏劑2,5-二苯基噻吩和2,5-二乙炔苯基噻吩,併研究瞭所閤成的光敏劑的對斜紋夜蛾細胞的光活化毒力、單線態氧及光穩定性。[結果]光敏劑2,5-二苯基噻吩對斜紋夜蛾細胞的24和48 h的抑製中濃度IC50值分彆為0.22和0.16μg/ml,2,5-二乙炔苯基噻吩斜紋夜蛾細胞的24和48 h的抑製中濃度 IC50值分彆為0.06和0.04μg/ml;在紫外光照下,光敏劑2,5-二苯基噻吩和2,5-二乙炔苯基噻吩產生的1O2能力分彆為1.0475和1.5294μg/mmol;2,5-二苯基噻吩和2,5-二乙炔苯基噻吩在甲醇中降解動力學方程分彆為 Ct=5.2271e-0.061t和 Ct=5.0842e-0.0973t,其半衰期分彆為111.79和7.12 h。[結論]所閤成的光敏劑2,5-二苯基噻吩具有良好的光活化激髮產生單線態氧的能力,對斜紋夜蛾SL細胞具有良好的光活化毒殺作用,剋服瞭光活化殺蟲劑見光易分解等不足,因此2,5-二苯基噻吩具有開髮成光活化殺蟲劑的潛力。
[목적]제고광민제적광은정성,연장광민제재배경중적반쇠기。[방법]해연구이전형광민제α-삼련새분위모판,이용생물등배원리,이분배대체새분배,합성료광민제2,5-이분기새분화2,5-이을결분기새분,병연구료소합성적광민제적대사문야아세포적광활화독력、단선태양급광은정성。[결과]광민제2,5-이분기새분대사문야아세포적24화48 h적억제중농도IC50치분별위0.22화0.16μg/ml,2,5-이을결분기새분사문야아세포적24화48 h적억제중농도 IC50치분별위0.06화0.04μg/ml;재자외광조하,광민제2,5-이분기새분화2,5-이을결분기새분산생적1O2능력분별위1.0475화1.5294μg/mmol;2,5-이분기새분화2,5-이을결분기새분재갑순중강해동역학방정분별위 Ct=5.2271e-0.061t화 Ct=5.0842e-0.0973t,기반쇠기분별위111.79화7.12 h。[결론]소합성적광민제2,5-이분기새분구유량호적광활화격발산생단선태양적능력,대사문야아SL세포구유량호적광활화독살작용,극복료광활화살충제견광역분해등불족,인차2,5-이분기새분구유개발성광활화살충제적잠력。
Objective The aim of this study was to improve the photostability of pho-tosensitizers. [Method] 2,5-Diphenylthiophene and 2,5-dithienylethynylthiophene were synthesized by replacing thiophene rings of α-terthienyl (α-T) with benzene rings. Photoactivated activities on Spodoptera litura (SL) cells, singlet oxygen with UV and photostability of photosensitizers were investigated. [Result] The cytotoxicity of pho-tosensitizer 2,5-diphenylthiophene on SL cells was 0.22 and 0.16 μg/ml after treat-ment for 24 and 48 h, respectively, while that of 2,5-dithienylethynylthiophene on SL cells was 0.06 and 0.04 μg/ml. Singlet oxygen of 2,5-diphenylthiophene and 2,5-dithienylethynylthiophene was 1.047 5, 1.529 4 μg/mmol under UV, respectively. Degradation dynamic equations of 2,5-diphenylthiophene and 2,5-dithienylethynylthio-phene in methanol were Ct= 5.227 1e-0.006 1t, Ct= 5.084 2e-0.097 3t and half life was 111.79, 7.12 h. [Conclusion] Photosensitizer 2,5-diphenylthiophene has high singlet oxygen production ability, and high photoactivated cytotoxicity on SL cells under UV. Moreover, 2,5-diphenylthiophene has overcome the deficiency of photoactivated in-secticides, which is not applied directly in field because it degrades quickly in the environment.