CAJ | 학술논문

目的：探讨MCV、MCH及血清铁蛋白联合应用在地中海贫血中的诊断意义。方法健康对照组60例，地中海贫血杂合子携带者120例，应用Beckman-Coulter （贝克曼-库尔特） LH750型五分类血细胞分析仪检测红细胞MCV、MCH。用化学发光法测定血清铁蛋白。结果地贫组和IDA组MCV、MCH 均减低，两者与健康对照组比较，差异均有统计学意义（ P＜0.01）。地贫组与IDA组比较，地贫组MCV较IDA组明显减低，两者之间差异有统计学意义（ P＜0.01）。 IDA组SF降低，而地贫组SF不低，两者之间差异有统计学意义（ P＜0.01）。结论（1）MCV、MCH及血清铁蛋白可作为筛查孕妇地贫的有效指标；（2）做好产前地贫的筛查，对预防和降低重型地贫患儿出生具有重要意义。
목적：탐토MCV、MCH급혈청철단백연합응용재지중해빈혈중적진단의의。방법건강대조조60례，지중해빈혈잡합자휴대자120례，응용Beckman-Coulter （패극만-고이특） LH750형오분류혈세포분석의검측홍세포MCV、MCH。용화학발광법측정혈청철단백。결과지빈조화IDA조MCV、MCH 균감저，량자여건강대조조비교，차이균유통계학의의（ P＜0.01）。지빈조여IDA조비교，지빈조MCV교IDA조명현감저，량자지간차이유통계학의의（ P＜0.01）。 IDA조SF강저，이지빈조SF불저，량자지간차이유통계학의의（ P＜0.01）。결론（1）MCV、MCH급혈청철단백가작위사사잉부지빈적유효지표；（2）주호산전지빈적사사，대예방화강저중형지빈환인출생구유중요의의。
Objective To investigate the MCV , MCH and serum ferritin in the diagnosis of thalassemia joint applica-tion.Methods In healthy control group of 60 patients with thalassemia heterozygous carriers 120 cases, the application Beckman.Coulter ( Beckman-Coulter ) LH750-type five categories of blood cell analyzer erythrocyte MCV , MCH.Serum ferritin by chemiluminescence.Results Thalassemia group and IDA group MCV , MCH were reduced , both with the healthy control group , the difference was statistically significant ( P<0.01 ) thalassemia group and IDA group., MCV thalassemia group was significantly lower than the IDA group , there was significant difference between the two ( P<0.01 ).IDA SF group decreased , while thalassemia group SF is not low , the difference between the two was statistical-ly significant (P<0.01).Conclusions (1)MCV, MCH and serum ferritin screening of pregnant women as an effective indicator of thalassemia;(2)do prenatal screening for thalassemia , to prevent and reduce heavy significance in children born with thalassemia.