航空航天医学杂志
航空航天醫學雜誌
항공항천의학잡지
AEROSPACE MEDICINE
2014年
5期
599-600
,共2页
p53%食道鳞状细胞癌%分化%预后
p53%食道鱗狀細胞癌%分化%預後
p53%식도린상세포암%분화%예후
p53%Esophageal squamous cell carcinoma%Differentiation%Prognosis
目的：探讨p53在食道癌中的表达及与淋巴结转移的关系。方法收集2011年1月～2013年12月经病理检查确诊的食道鳞状细胞癌根治标本154例，其中高分化鳞癌39例、中分化鳞癌56例、低分化鳞癌59例，经常规取材、脱水、透明、浸蜡、包埋、切片、HE染色后镜下观察淋巴结转移情况；并选取癌组织行免疫组化（ S-P法）检测p53。结果154例病例中，高分化鳞癌p53阳性率41％，中分化鳞癌p53阳性率54.2％，低分化鳞癌p53阳性率67.8％；p53阳性而有淋巴结转移者58例、p53阴性而有淋巴结转移者29例。各组间经χ2检验，高分化与中分化及中分化与低分化比较，χ2值分别为2.4及1.38、P＞0.1，无统计学意义；但高分化与低分化比较，χ2值6.89、P＜0.01，具有统计学意义；p53阳性伴淋巴结转移率明显高于p53阴性病例，经检验，χ2值为7.44，P＜0.01，亦具有统计学意义。结论 p53可作为食道鳞状细胞癌重要的预后参考指标。
目的：探討p53在食道癌中的錶達及與淋巴結轉移的關繫。方法收集2011年1月～2013年12月經病理檢查確診的食道鱗狀細胞癌根治標本154例，其中高分化鱗癌39例、中分化鱗癌56例、低分化鱗癌59例，經常規取材、脫水、透明、浸蠟、包埋、切片、HE染色後鏡下觀察淋巴結轉移情況；併選取癌組織行免疫組化（ S-P法）檢測p53。結果154例病例中，高分化鱗癌p53暘性率41％，中分化鱗癌p53暘性率54.2％，低分化鱗癌p53暘性率67.8％；p53暘性而有淋巴結轉移者58例、p53陰性而有淋巴結轉移者29例。各組間經χ2檢驗，高分化與中分化及中分化與低分化比較，χ2值分彆為2.4及1.38、P＞0.1，無統計學意義；但高分化與低分化比較，χ2值6.89、P＜0.01，具有統計學意義；p53暘性伴淋巴結轉移率明顯高于p53陰性病例，經檢驗，χ2值為7.44，P＜0.01，亦具有統計學意義。結論 p53可作為食道鱗狀細胞癌重要的預後參攷指標。
목적：탐토p53재식도암중적표체급여림파결전이적관계。방법수집2011년1월～2013년12월경병리검사학진적식도린상세포암근치표본154례，기중고분화린암39례、중분화린암56례、저분화린암59례，경상규취재、탈수、투명、침사、포매、절편、HE염색후경하관찰림파결전이정황；병선취암조직행면역조화（ S-P법）검측p53。결과154례병례중，고분화린암p53양성솔41％，중분화린암p53양성솔54.2％，저분화린암p53양성솔67.8％；p53양성이유림파결전이자58례、p53음성이유림파결전이자29례。각조간경χ2검험，고분화여중분화급중분화여저분화비교，χ2치분별위2.4급1.38、P＞0.1，무통계학의의；단고분화여저분화비교，χ2치6.89、P＜0.01，구유통계학의의；p53양성반림파결전이솔명현고우p53음성병례，경검험，χ2치위7.44，P＜0.01，역구유통계학의의。결론 p53가작위식도린상세포암중요적예후삼고지표。
Objective To investgae the reliability expression of p 53 in esophageal cancer and relationship between expression of p53 and the lymph node metastasis.Methods Collect pathological examination confirmed 154 cases of e-sophageal squamous cell carcinoma radical specimen of our department between 2011 January and 2013 December.A-mong them, 39 cases of highly differentiated squamous carcinoma , 56 cases of moderate differentiated squamous carcino-ma, 59 cases of poorly differentiated squamous carcinoma , through regular based dehydration、transparent、paraffin em-bedding、sectioning,and microscopically observed after HE staining with lymph node metastasis.The expression of p53 in the selective tumor tissue was detected by immunohistochemistry (S-P methods).Results In the 154 cases, the ex-pression of p53 was 41%in the highly differentiated squamous carcinoma , 54.2% in the moderate differentiated squa-mous carcinoma and 67.8%in the poorly differentiated squamous carcinoma.58 cases with lymph node metastasis were p53 positive, 29 cases with lymph node metastasis were p 53 negative.Each group by X2 test, X2value respectively were 2.4 and 1.38 in comparison of highly differentiated squamous carcinoma vs moderate differentiated squamous carcinoma and moderate differentiated squamous carcinoma vs poorly differentiated squamous carcinoma .The P>0.1 ,there were no statistically significant.But X2 value was 6.89 and P<0.01 in comparison of highly differentiated squamous carcinoma vs poorly differentiated squamous carcinoma , which did differ significantly.The rate of P53 positive associated with lymph node metastasis was significantly higher than the p 53 negative cases.By X2test, X2value was 6.89 and P<0.01, which did differ significantly.Conclusions p53 can be taken as a important indicators of the prognosis of esophageal squamous cell carcinoma.
