CAJ | 학술논문

胰岛素样生长因子结合蛋白7( IGFBP7)属于胰岛素样生长因子结合蛋白超家族成员，参与细胞内信号转导、细胞生长及细胞代谢，在人类多种组织中均有表达。 IGFBP7在银屑病患者表皮中表达显著降低，其参与银屑病发病的机制可能为通过胰岛素及IGFs等信号途径抑制角质形成细胞增殖、诱导其分化及凋亡，下调VEGF的表达从而抑制新生血管生成。维A酸类药物治疗银屑病取得较好疗效，可能与其直接或间接调节IGFs的活性，上调IGFBP7及其mRNA的表达相关。
이도소양생장인자결합단백7( IGFBP7)속우이도소양생장인자결합단백초가족성원，삼여세포내신호전도、세포생장급세포대사，재인류다충조직중균유표체。 IGFBP7재은설병환자표피중표체현저강저，기삼여은설병발병적궤제가능위통과이도소급IGFs등신호도경억제각질형성세포증식、유도기분화급조망，하조VEGF적표체종이억제신생혈관생성。유A산류약물치료은설병취득교호료효，가능여기직접혹간접조절IGFs적활성，상조IGFBP7급기mRNA적표체상관。
Insulin-like growth factor-binding protein 7 ( IGFBP7) a member of IGFBP superfamily involving in intracellular signaling cell growth and cell metabolism is expressed in a wide variety of human tissues. IGFBP7 expression is significantly reduced in psoriatic lesion. The role of IGFBP7 in the pathogenesis of psoriasis is the induction of cell differentiation and apoptosis alleviation of keratinocyte proliferation abnormalities and down-regulation of the VEGF expression to inhibit angiogenesis. Retinoids are acknowledged as effective drugs for psoriasis and the potential mechanism is related to the regulation of IGFs directly or indirectly and up-regulation of IGFBP7 mRNA and protein.