中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
10期
1763-1764
,共2页
欧阳杰湖%彭献献%李瑞莲
歐暘傑湖%彭獻獻%李瑞蓮
구양걸호%팽헌헌%리서련
磷酸可待因片%细胞毒性%辅料
燐痠可待因片%細胞毒性%輔料
린산가대인편%세포독성%보료
Codeinephosphatetablets%Cytotoxicity%Excipients
目的：：比较两个企业的磷酸可待因片剂的处方优劣。方法：检测两个企业的磷酸可待因的片剂、原料和辅料的细胞毒性。结果：A企业片剂的IC50值为0.169 mg·ml-1,B企业片剂的IC50值为0.140 mg·ml-1,两企业片剂的IC50值差异有统计学意义(P<0.05)；两企业原料的IC50值差异无统计学意义(P>0.05)。结论：两企业磷酸可待因片剂的细胞毒性差异主要由辅料不同导致,A企业处方优于B企业。
目的：：比較兩箇企業的燐痠可待因片劑的處方優劣。方法：檢測兩箇企業的燐痠可待因的片劑、原料和輔料的細胞毒性。結果：A企業片劑的IC50值為0.169 mg·ml-1,B企業片劑的IC50值為0.140 mg·ml-1,兩企業片劑的IC50值差異有統計學意義(P<0.05)；兩企業原料的IC50值差異無統計學意義(P>0.05)。結論：兩企業燐痠可待因片劑的細胞毒性差異主要由輔料不同導緻,A企業處方優于B企業。
목적：：비교량개기업적린산가대인편제적처방우렬。방법：검측량개기업적린산가대인적편제、원료화보료적세포독성。결과：A기업편제적IC50치위0.169 mg·ml-1,B기업편제적IC50치위0.140 mg·ml-1,량기업편제적IC50치차이유통계학의의(P<0.05)；량기업원료적IC50치차이무통계학의의(P>0.05)。결론：량기업린산가대인편제적세포독성차이주요유보료불동도치,A기업처방우우B기업。
Objective:To compare the formula of codeine phosphate tablets produced by two enterprises. Methods: IC50 of the tablets and raw material of codeine phosphate, and the excipients from two enterprises was detected respectively. Results:IC50 of the tablets from A enterprise was 0. 169 mg·ml-1 , that from B enterprise was 0. 140 mg·ml-1 , and the difference was statistically sig-nificant(P<0. 05). IC50 of the raw material from the two enterprises showed no notable difference (P>0. 05). Conclusion: The difference in cytotoxicity of codeine phosphate tablets is manly induced by the excipients, and the products from A enterprise are better than those from B enterprise.
