中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
10期
1702-1704
,共3页
药物性肝损伤%乙型病毒性肝炎%临床特点%回顾性分析
藥物性肝損傷%乙型病毒性肝炎%臨床特點%迴顧性分析
약물성간손상%을형병독성간염%림상특점%회고성분석
Drug-inducedliverinjury%HepatitisB%Clinicalcharacters%Retrospectiveanalysis
目的：：通过分析药物性肝损伤( DILI)合并乙型病毒性肝炎患者的临床特点，提高医务工作者对该疾病的认识与重视。方法：采用回顾性分析方法，对某三甲综合医院住院部2013~2014年诊断为DILI合并乙肝的患者进行分析。结果：共收集30例DILI合并乙肝病例，男性多于女性，以中老年患者居多。患者常出现乏力、纳差、皮肤巩膜黄染、厌油、恶心、腹胀等症状。重度肝损占80.0%，中、轻度肝损分别占16.7%、3.3%。肝损伤类型混合型(13例)居多，其次为肝细胞型(10例)、胆汁淤积型(7例)。结论：DILI合并乙肝在中老年男性中易发，临床表现复杂多样，肝损伤以重度为主，往往表现为混合型肝损伤。
目的：：通過分析藥物性肝損傷( DILI)閤併乙型病毒性肝炎患者的臨床特點，提高醫務工作者對該疾病的認識與重視。方法：採用迴顧性分析方法，對某三甲綜閤醫院住院部2013~2014年診斷為DILI閤併乙肝的患者進行分析。結果：共收集30例DILI閤併乙肝病例，男性多于女性，以中老年患者居多。患者常齣現乏力、納差、皮膚鞏膜黃染、厭油、噁心、腹脹等癥狀。重度肝損佔80.0%，中、輕度肝損分彆佔16.7%、3.3%。肝損傷類型混閤型(13例)居多，其次為肝細胞型(10例)、膽汁淤積型(7例)。結論：DILI閤併乙肝在中老年男性中易髮，臨床錶現複雜多樣，肝損傷以重度為主，往往錶現為混閤型肝損傷。
목적：：통과분석약물성간손상( DILI)합병을형병독성간염환자적림상특점，제고의무공작자대해질병적인식여중시。방법：채용회고성분석방법，대모삼갑종합의원주원부2013~2014년진단위DILI합병을간적환자진행분석。결과：공수집30례DILI합병을간병례，남성다우녀성，이중노년환자거다。환자상출현핍력、납차、피부공막황염、염유、악심、복창등증상。중도간손점80.0%，중、경도간손분별점16.7%、3.3%。간손상류형혼합형(13례)거다，기차위간세포형(10례)、담즙어적형(7례)。결론：DILI합병을간재중노년남성중역발，림상표현복잡다양，간손상이중도위주，왕왕표현위혼합형간손상。
Objective:To analyze the clinical features of the patients with drug-induced liver injury ( DILI) combined with hepati-tis B to improve the awareness and attention to the disease by medical workers. Methods:Using retrospective analysis, the patients di-agnosed with DILI combined with hepatitis B from a tertiary-hospital were analyzed from January 2013 to January 2014. Results:Total-ly 30 cases of DILI combined with hepatitis B were collected, the number of male patients was higher than that of female patients, and most of them were elderly patients. The symptoms included weak, anorexia, yellow skin and sclera, tired of the oil, nausea, abdominal distension and so on. The patients with severe liver damage accounted for 80. 0%, 16. 7% was with moderate liver damage, and 3. 3%was with mild liver damage. Thirteen cases were mixed type, ten cases were hepatocellular type, and seven cases were cholestatic type. Conclusion:Middle-aged men may be prone to the disease, and the clinical manifestations are complex and diverse. Severe liver damage is majority, and often shows as mixed liver injury.
