中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
10期
1700-1701,1702
,共3页
糖尿病胃轻瘫%阿奇霉素%莫沙必利%复发
糖尿病胃輕癱%阿奇黴素%莫沙必利%複髮
당뇨병위경탄%아기매소%막사필리%복발
Diabeticgastroparesis%Azithromycin%Mosapride%Reoccurrence
目的：：探讨阿奇霉素与莫沙必利联合治疗糖尿病胃轻瘫的疗效及安全性。方法：糖尿病胃轻瘫患者70例随机分为观察组和对照组。两组患者均予药物控制血糖(胰岛素注射或降糖药口服)。观察组患者予阿奇霉素肠溶片0.25 g,po,qd,莫沙必利片5 mg,po,tid联合治疗,对照组患者予单纯莫沙必利片5 mg,po,tid治疗,两组疗程均为4周。观察两组患者治疗后的临床疗效及药物不良反应,比较治疗后随访1年的复发率。结果：治疗4周后,观察组临床总有效率明显高于对照组(94.29% vs.77.14%,P<0.05)；两组不良反应发生率比较差异无统计学意义(P>0.05)。随访1年,观察组复发率明显低于对照组(P<0.05)。结论：阿奇霉素与莫沙必利联合治疗糖尿病胃轻瘫疗效肯定,安全性较好,并能有效降低患者的复发率。
目的：：探討阿奇黴素與莫沙必利聯閤治療糖尿病胃輕癱的療效及安全性。方法：糖尿病胃輕癱患者70例隨機分為觀察組和對照組。兩組患者均予藥物控製血糖(胰島素註射或降糖藥口服)。觀察組患者予阿奇黴素腸溶片0.25 g,po,qd,莫沙必利片5 mg,po,tid聯閤治療,對照組患者予單純莫沙必利片5 mg,po,tid治療,兩組療程均為4週。觀察兩組患者治療後的臨床療效及藥物不良反應,比較治療後隨訪1年的複髮率。結果：治療4週後,觀察組臨床總有效率明顯高于對照組(94.29% vs.77.14%,P<0.05)；兩組不良反應髮生率比較差異無統計學意義(P>0.05)。隨訪1年,觀察組複髮率明顯低于對照組(P<0.05)。結論：阿奇黴素與莫沙必利聯閤治療糖尿病胃輕癱療效肯定,安全性較好,併能有效降低患者的複髮率。
목적：：탐토아기매소여막사필리연합치료당뇨병위경탄적료효급안전성。방법：당뇨병위경탄환자70례수궤분위관찰조화대조조。량조환자균여약물공제혈당(이도소주사혹강당약구복)。관찰조환자여아기매소장용편0.25 g,po,qd,막사필리편5 mg,po,tid연합치료,대조조환자여단순막사필리편5 mg,po,tid치료,량조료정균위4주。관찰량조환자치료후적림상료효급약물불량반응,비교치료후수방1년적복발솔。결과：치료4주후,관찰조림상총유효솔명현고우대조조(94.29% vs.77.14%,P<0.05)；량조불량반응발생솔비교차이무통계학의의(P>0.05)。수방1년,관찰조복발솔명현저우대조조(P<0.05)。결론：아기매소여막사필리연합치료당뇨병위경탄료효긍정,안전성교호,병능유효강저환자적복발솔。
Objective:To explore the efficacy and safety of azithromycin combined with mosapride in the patients with diabetic gastroparesis ( DGP) . Methods:Totally 70 cases of patients with DGP were randomly divided into the observation group and the control group. All the patients were given drugs to control the blood sugar ( injection of insulin or oral administration of hypoglycemic drugs) . The patients in the observation group were given azithromycin enteric-coated tablets 0. 25g per time, once a day, and mosapride tablets 5mg per time, three times a day, while the patients in the control group were only given mosapride tablets 5mg per time, three times a day. The treatment course was 4 weeks. The clinical curative effect and drug adverse reactions ( ADR) in the two groups after the med-ical treatment were observed, and the reoccurrence rate after one-year following-up was compared as well. Results: After the 4-week treatment, the total clinical efficiency in the observation group was much higher than that in the control group (94. 29% vs. 77. 14%, P<0. 05). The incidence of ADR in the two groups showed no statistical difference (P>0. 05). The reoccurrence rate in the observa-tion group was much lower than that in the control group (P<0. 05). Conclusion:Azithromycin combined with mosapride shows reli-able curative effect in the patients with DGP with high security, which can effectively reduce the reoccurrence rate of the patients.
