中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
10期
1672-1674
,共3页
李旸%陈晨%李银科%胡晓%廖祥茹%韩亮%陈鹰
李旸%陳晨%李銀科%鬍曉%廖祥茹%韓亮%陳鷹
리양%진신%리은과%호효%료상여%한량%진응
复方积雪草苷%凝胶贴膏%基质%制备工艺
複方積雪草苷%凝膠貼膏%基質%製備工藝
복방적설초감%응효첩고%기질%제비공예
Compoundasiaticoside%Gelplasters%Matrix%Preparation
目的：：筛选复方积雪草苷凝胶贴膏的处方，确定最佳制备工艺。方法：采用正交设计法，以凝胶贴膏的初黏力、持黏力、综合外观为考察指标，对复方积雪草苷凝胶贴膏进行综合评分，考察不同基质辅料比例对复方积雪草苷凝胶贴膏的影响，优选最佳处方工艺。结果：最佳处方基质配比为甘羟铝∶EDTA∶甘油∶CMC-Na=0.25∶0.05∶45∶1。结论：按照最佳工艺条件制备的复方积雪草苷凝胶贴膏黏附力好，外观涂布均匀，能适应大生产的需要。
目的：：篩選複方積雪草苷凝膠貼膏的處方，確定最佳製備工藝。方法：採用正交設計法，以凝膠貼膏的初黏力、持黏力、綜閤外觀為攷察指標，對複方積雪草苷凝膠貼膏進行綜閤評分，攷察不同基質輔料比例對複方積雪草苷凝膠貼膏的影響，優選最佳處方工藝。結果：最佳處方基質配比為甘羥鋁∶EDTA∶甘油∶CMC-Na=0.25∶0.05∶45∶1。結論：按照最佳工藝條件製備的複方積雪草苷凝膠貼膏黏附力好，外觀塗佈均勻，能適應大生產的需要。
목적：：사선복방적설초감응효첩고적처방，학정최가제비공예。방법：채용정교설계법，이응효첩고적초점력、지점력、종합외관위고찰지표，대복방적설초감응효첩고진행종합평분，고찰불동기질보료비례대복방적설초감응효첩고적영향，우선최가처방공예。결과：최가처방기질배비위감간려∶EDTA∶감유∶CMC-Na=0.25∶0.05∶45∶1。결론：안조최가공예조건제비적복방적설초감응효첩고점부력호，외관도포균균，능괄응대생산적수요。
Objective: To optimize the formula of compound asiaticoside gel plasters, and determine the optimal preparation process. Methods:Using the initial adhesion, viscosity and appearance as the indices, the gel plasters were evaluated by orthogonal design in order to study the effects of various base ratios on the preparation and screen the optimal formula and preparation process. Re-sults:The optimal formula was dihydroxyaluminium aminoacetate∶EDTA∶glycerol∶CMC-Na of 0. 25∶0. 05∶45∶1. Conclusion: Com-pound asiaticoside gel plasters with the optimal formula and preparation technique show good adhesion and uniformity, which can meet the need of large-scale production.
