CAJ | 학술논문

目的通过文献综合分析航天飞行和地面模拟微重力环境对多种免疫细胞活性与功能的影响. 资料来源与选择选择国内外该领域的相关研究论文和专著. 资料引用国内外公开发表的文献50篇. 资料综合来自长期航天飞行实践和地面模拟研究的结果均发现微重力环境影响多种免疫细胞活性与功能的现象,包括免疫细胞数量和亚群的改变,T细胞增殖活性的降低,多种细胞因子分泌水平的变化等. 结论微重力环境可能是通过改变细胞表面受体及细胞功能基因的表达,影响细胞内信号通路的传递和细胞表观遗传事件等对免疫细胞产生负面影响.未来的研究应当进一步明确免疫细胞感受重力的分子机制,寻找能够逆转微重力环境下免疫细胞功能受到抑制的方法,为开展长期太空科学研究和空间生活提供保障.
목적 통과문헌종합분석항천비행화지면모의미중력배경대다충면역세포활성여공능적영향. 자료래원여선택 선택국내외해영역적상관연구논문화전저. 자료인용 국내외공개발표적문헌50편. 자료종합 래자장기항천비행실천화지면모의연구적결과균발현미중력배경영향다충면역세포활성여공능적현상,포괄면역세포수량화아군적개변,T세포증식활성적강저,다충세포인자분비수평적변화등. 결론 미중력배경가능시통과개변세포표면수체급세포공능기인적표체,영향세포내신호통로적전체화세포표관유전사건등대면역세포산생부면영향.미래적연구응당진일보명학면역세포감수중력적분자궤제,심조능구역전미중력배경하면역세포공능수도억제적방법,위개전장기태공과학연구화공간생활제공보장.
Objective To summarize the effects of space flight and ground simulated microgravity environment on immune cell's activity and functions.Literature resource and selection Domestic and international publications in this field were carefully retrieved.Literature quotation Fifty published research papers and reviews were cited.Literature synthesis Many studies have demonstrated that microgravity of space flight and simulated microgravity can affect the activity and functions of many kinds of immune cells,including altering the number and subset ratio of immune cells,reducing the mitogen-stimulated proliferation activity of T cells and affecting the secretion of cytokines,etc..Conclusions Microgravity can certainly cause negative effects on immune cells.Some fundamental cellular processes,such as expression of cell surface receptors,regulation of functional genes,transmission of signal pathways and epigenetic events may contribute to the effects of microgravity on immune cells.For further understanding of the effects of microgravity on immune cells,future studies should focus on the molecular mechanism among those related receptors,transduction signals and regulation genes.Countermeasures for preventing,such as the process of restoring immune cell's function from the restrain of microgravity effects,are expected.It will provide support for developing long-term space scientific research and space life.