CAJ | 학술논문

目的：了解金黄色葡萄球菌（SAU）的临床分布及耐药情况。方法收集2009-2012年微生物室分离培养的SAU，采用细菌鉴定分析仪及配套的鉴定条和药敏条对菌株进行鉴定和药敏实验。结果共检出672株SAU，其中耐甲氧西林金黄色葡萄球菌（MRSA）365株，占54.3%，甲氧西林敏感金黄色葡萄球菌（MSSA）307株，占45.7%。SAU主要分离自重症监护室、骨科和心血管科。MRSA主要分离自重症监护室、骨科和神经内科。痰标本中分离的MRSA最多，其次为脓液分泌物。MRSA对大多数抗生素耐药，其耐药率＜50.0%的抗生素有利福平、万古霉素、复方磺胺甲恶唑、喹奴普汀-达福普汀、替考拉宁和呋喃妥因等。MSSA对除青霉素外的大多数抗生素敏感。未发现耐万古霉素菌株。结论 SAU临床分布广泛，MRSA检出率较高，应加强SAU耐药性监测。
목적：료해금황색포도구균（SAU）적림상분포급내약정황。방법수집2009-2012년미생물실분리배양적SAU，채용세균감정분석의급배투적감정조화약민조대균주진행감정화약민실험。결과공검출672주SAU，기중내갑양서림금황색포도구균（MRSA）365주，점54.3%，갑양서림민감금황색포도구균（MSSA）307주，점45.7%。SAU주요분리자중증감호실、골과화심혈관과。MRSA주요분리자중증감호실、골과화신경내과。담표본중분리적MRSA최다，기차위농액분비물。MRSA대대다수항생소내약，기내약솔＜50.0%적항생소유리복평、만고매소、복방광알갑악서、규노보정-체복보정、체고랍저화부남타인등。MSSA대제청매소외적대다수항생소민감。미발현내만고매소균주。결론 SAU림상분포엄범，MRSA검출솔교고，응가강SAU내약성감측。
Objective To investigate the distribution and drug resistance of Staphylococcus aureus (SAU) in Zhoushan during 2009-2012. Method SAU isolates from Zhoushan hospitals during 2009 to 2012 were identified with automatic microor-ganism analyzer and the drug susceptibility testing was performed by using matched ATB- test paper. Results Total 672 strains of SAU were isolated including 365 strains of methicillin resistant Staphylococcus aureus(MRSA) and 307strains of methicil in sus-ceptible Staphylococcus aureus(MSSA). Of al SAU strains, 80 were isolated from intensive care unit(ICU), 80 from department of orthopedics and 50 from cardiovascular department. Of al MRSA strains, 55 were isolated from ICU, 36 from department of or-thopedics and 35 from neurology department. Among al MRSA 175 strains were isolated from sputum samples, 124 from fester secretion. MRSA were resistant to most antimicrobial agents, the resistance rates to rifampicin, vancomycin, compound sul-famethoxazole, quinoline slave leptin- dufour leptin, teicoplanin and furantoin were below 50.0%. MSSA were sensitive to most antimicrobial agents, except penicil in. No resistant to vancomycin strains were found in this study. Conclusion The clinical dis-tribution of SAU was extensive in Zhoushan hospitals and the isolation rate of MRSA is high.