浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
9期
770-771,784
,共3页
带状疱疹后遗神经痛%糖代谢异常%小纤维神经病
帶狀皰疹後遺神經痛%糖代謝異常%小纖維神經病
대상포진후유신경통%당대사이상%소섬유신경병
Postherpetic neuralgia%Abnormal glucose metabolism%Smal fibers neuropathy
目的：调查并分析带状疱疹后遗神经痛（PHN）患者糖代谢异常情况。方法选取确诊胸部PHN患者31例，及其无疼痛、无已知神经功能障碍和糖尿病史的配偶或直系亲属62例作为对照组，记录两组一般资料以及体重指数（BMI）、腰围、糖化血红蛋白（HbA1c）；检测PHN患者空腹和口服葡萄糖耐量试验（2h- OGTT）后血糖和胰岛素水平以评价小纤维神经病。结果两组性别、年龄、空腹血糖和胰岛素水平、腰围、稳态模型评价（HOMA）指数、HbA1c水平的差异均无统计学意义（均P＞0.05）；两组糖代谢异常（糖耐量受损+糖尿病）发生率，尤其糖耐量受损的差异有统计学意义（P＜0.05）；31例PHN患者中发现有小纤维神经病14例，与糖代谢正常者相比，合并糖代谢异常，尤其合并糖耐量受损患者中小纤维神经病发生率增加，差异有统计学意义（P＜0.05）。结论 PHN患者糖代谢异常明显增加，PHN合并糖代谢异常（糖耐量受损+糖尿病），尤其合并糖耐量受损患者小纤维神经病发生率增加。
目的：調查併分析帶狀皰疹後遺神經痛（PHN）患者糖代謝異常情況。方法選取確診胸部PHN患者31例，及其無疼痛、無已知神經功能障礙和糖尿病史的配偶或直繫親屬62例作為對照組，記錄兩組一般資料以及體重指數（BMI）、腰圍、糖化血紅蛋白（HbA1c）；檢測PHN患者空腹和口服葡萄糖耐量試驗（2h- OGTT）後血糖和胰島素水平以評價小纖維神經病。結果兩組性彆、年齡、空腹血糖和胰島素水平、腰圍、穩態模型評價（HOMA）指數、HbA1c水平的差異均無統計學意義（均P＞0.05）；兩組糖代謝異常（糖耐量受損+糖尿病）髮生率，尤其糖耐量受損的差異有統計學意義（P＜0.05）；31例PHN患者中髮現有小纖維神經病14例，與糖代謝正常者相比，閤併糖代謝異常，尤其閤併糖耐量受損患者中小纖維神經病髮生率增加，差異有統計學意義（P＜0.05）。結論 PHN患者糖代謝異常明顯增加，PHN閤併糖代謝異常（糖耐量受損+糖尿病），尤其閤併糖耐量受損患者小纖維神經病髮生率增加。
목적：조사병분석대상포진후유신경통（PHN）환자당대사이상정황。방법선취학진흉부PHN환자31례，급기무동통、무이지신경공능장애화당뇨병사적배우혹직계친속62례작위대조조，기록량조일반자료이급체중지수（BMI）、요위、당화혈홍단백（HbA1c）；검측PHN환자공복화구복포도당내량시험（2h- OGTT）후혈당화이도소수평이평개소섬유신경병。결과량조성별、년령、공복혈당화이도소수평、요위、은태모형평개（HOMA）지수、HbA1c수평적차이균무통계학의의（균P＞0.05）；량조당대사이상（당내량수손+당뇨병）발생솔，우기당내량수손적차이유통계학의의（P＜0.05）；31례PHN환자중발현유소섬유신경병14례，여당대사정상자상비，합병당대사이상，우기합병당내량수손환자중소섬유신경병발생솔증가，차이유통계학의의（P＜0.05）。결론 PHN환자당대사이상명현증가，PHN합병당대사이상（당내량수손+당뇨병），우기합병당내량수손환자소섬유신경병발생솔증가。
Objective To analyze glucose metabolism in patients with postherpetic neuralgia (PHN). Methods 31 pa-tients with thoracic PHN (PHN group) and 62 healthy subjects (control group) were enrolled in the study. The anamnestic data (dietary habits, life style, drug use), demographic information (age, sex), body mass index, waist circumference and serum HbA1c were documented in both groups;the glucose and insulin levels at fasting and after 2h- OGTT were measured and skin thoracic biopsy was performed for smal fiber neuropathy in PHN groups. Results Medical records and demographic information were not significantly different between two groups(P>0.05). 2h- OGTT showed that the prevalence of glucose metabolism abnormal-ity was significantly higher in PHN group than that in control group, especial y for impaired glucose tolerance (IGT) (P<0.05). Skin biopsy detected smal fibers neuropathy in 14 out of 31 patients with PHN;PHN patients with abnormal glucose metabolism, es-pecial y IGT had higher prevalence of smal fibers neuropathy (P<0.05). Conclusion Patients with PHN have higher prevalence of abnormal glucose metabolism and PHN Patients with abnormal glucose metabolism have higher prevalence of smal fibers neuropathy.
