CAJ | 학술논문

目的：探讨糖化血红蛋白（HbA1c）与青年急性心肌梗死的相关性。方法：收集2009年1月至2012年8月于我院诊断急性心梗的青年患者（年龄≤44岁）72例为青年心梗组，选取同期行冠状动脉造影排外冠心病的青年患者79例为青年对照组。研究患者的HbA1c及空腹血糖与青年急性心肌梗死的关系。结果：（1）与青年对照组比较，青年心梗组血浆空腹血糖、HbA1c明显升高（均P＜0．05）。（2）Logistic回归分析显示， HbA1c是与青年急性心梗独立相关的危险因素（OR＝1．365）。（3）在青年急性心梗组中，单支病变与双支及三支病变的HbA1c水平有显著差异（P＜0．05）。结论：HbA1c升高是青年急性心肌梗死的独立危险因素，且与患者的冠脉病变程度密切相关，早期干预糖代谢异常可能为青年心梗的防治提供新思路。
목적：탐토당화혈홍단백（HbA1c）여청년급성심기경사적상관성。방법：수집2009년1월지2012년8월우아원진단급성심경적청년환자（년령≤44세）72례위청년심경조，선취동기행관상동맥조영배외관심병적청년환자79례위청년대조조。연구환자적HbA1c급공복혈당여청년급성심기경사적관계。결과：（1）여청년대조조비교，청년심경조혈장공복혈당、HbA1c명현승고（균P＜0．05）。（2）Logistic회귀분석현시， HbA1c시여청년급성심경독립상관적위험인소（OR＝1．365）。（3）재청년급성심경조중，단지병변여쌍지급삼지병변적HbA1c수평유현저차이（P＜0．05）。결론：HbA1c승고시청년급성심기경사적독립위험인소，차여환자적관맥병변정도밀절상관，조기간예당대사이상가능위청년심경적방치제공신사로。
Objective To explore the association between HbA1c and acute myocardial infarction(AMI) in youth. Methods Seventy-two AMI patients (≤44y) diagnosed during the period from January in 2009 to August in 2012 were enrolled and 79 young age-matched adults without coronary artery disease at the same period were enrolled to be control group. The relationship between HbA1c, fasting blood-glucose(FBG) and AMI was explored. Results (1)Compared with the control group,the plasma FBG and HbA1C value were significantly higher(P<0.05) in AMI group. (2)Logistic regression analysis showed that HbA1c is the independent risk factor for AMI in youth. (3)In AMI group, the HbA1c level in single vessel disease had remarkable difference with that in double vessel disease and triple vessel disease(P<0.05). Conclusions Increasing HbA1c level is the independent risk factor for AMI in youth,and positively correlated with the degree of coronary artery lesions. Primary intervention of glycometabolism abnormality possibly becomes the new opinion for prevention and cure of AMI.