实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
9期
1394-1397
,共4页
王建平%周晨光%蒋超%余列%韩伟%王新新%付晓杰
王建平%週晨光%蔣超%餘列%韓偉%王新新%付曉傑
왕건평%주신광%장초%여렬%한위%왕신신%부효걸
脑梗死%浆细胞样树突状细胞%免疫炎症%C反应蛋白%NIHSS
腦梗死%漿細胞樣樹突狀細胞%免疫炎癥%C反應蛋白%NIHSS
뇌경사%장세포양수돌상세포%면역염증%C반응단백%NIHSS
Brain infarction%Plasmacytoid dendriticells%Immune-inflammation reaction%C-reactive protein%NIHSS
目的:探讨外周血浆细胞样树突状细胞与急性脑梗死后局部脑免疫炎症反应是否相关。方法:入选急性脑梗死患者(AIS组)62例,健康对照者(Control组)26例,无症状性脑梗死颈动脉狭窄患者(ACI-S组)12例,短暂性脑缺血发作患者(TIA组)14例,采用流式细胞分析检测各组外周血浆细胞样树突状细胞前体(pDCPs)数量。根据脑部磁共振弥散加权成像(DWI)图像评估梗死灶的大小,进一步将AIS组患者分为腔隙性脑梗死组、小梗死组、大梗死组,并比较不同亚组脑梗死患者pDCPs水平;并将AIS组患者pDCPs与NIHSS、CRP做相关分析。结果:AIS组与Control组相比,pDCPs占外周白细胞的比例及绝对数显著下降,差异具有统计学意义(P<0.001);与腔隙性脑梗死组相比,大梗死组患者pDCPs水平显著下降(P=0.001);且NIHSS评分和CRP与pDCPs均呈现明显的负相关。结论:急性脑梗死患者外周血pDCPs数量减少,可能与募集到梗死的脑组织参与炎症反应有关。
目的:探討外週血漿細胞樣樹突狀細胞與急性腦梗死後跼部腦免疫炎癥反應是否相關。方法:入選急性腦梗死患者(AIS組)62例,健康對照者(Control組)26例,無癥狀性腦梗死頸動脈狹窄患者(ACI-S組)12例,短暫性腦缺血髮作患者(TIA組)14例,採用流式細胞分析檢測各組外週血漿細胞樣樹突狀細胞前體(pDCPs)數量。根據腦部磁共振瀰散加權成像(DWI)圖像評估梗死竈的大小,進一步將AIS組患者分為腔隙性腦梗死組、小梗死組、大梗死組,併比較不同亞組腦梗死患者pDCPs水平;併將AIS組患者pDCPs與NIHSS、CRP做相關分析。結果:AIS組與Control組相比,pDCPs佔外週白細胞的比例及絕對數顯著下降,差異具有統計學意義(P<0.001);與腔隙性腦梗死組相比,大梗死組患者pDCPs水平顯著下降(P=0.001);且NIHSS評分和CRP與pDCPs均呈現明顯的負相關。結論:急性腦梗死患者外週血pDCPs數量減少,可能與募集到梗死的腦組織參與炎癥反應有關。
목적:탐토외주혈장세포양수돌상세포여급성뇌경사후국부뇌면역염증반응시부상관。방법:입선급성뇌경사환자(AIS조)62례,건강대조자(Control조)26례,무증상성뇌경사경동맥협착환자(ACI-S조)12례,단잠성뇌결혈발작환자(TIA조)14례,채용류식세포분석검측각조외주혈장세포양수돌상세포전체(pDCPs)수량。근거뇌부자공진미산가권성상(DWI)도상평고경사조적대소,진일보장AIS조환자분위강극성뇌경사조、소경사조、대경사조,병비교불동아조뇌경사환자pDCPs수평;병장AIS조환자pDCPs여NIHSS、CRP주상관분석。결과:AIS조여Control조상비,pDCPs점외주백세포적비례급절대수현저하강,차이구유통계학의의(P<0.001);여강극성뇌경사조상비,대경사조환자pDCPs수평현저하강(P=0.001);차NIHSS평분화CRP여pDCPs균정현명현적부상관。결론:급성뇌경사환자외주혈pDCPs수량감소,가능여모집도경사적뇌조직삼여염증반응유관。
Objective To explore the relation between plasmocytoid dentritic cells (pDCs) and cerebral immune-inflammation reaction following ischemic stroke. Methods Circulating pDCs were measured by flow cytometry in 62 patients with acute ischaemic stroke (AIS), 26 healthy controls, 12 patients with asymptomatic cerebral infarction stenosis (ACI-S), and 14 patients with transient ischaemic attack (TIA). The sizes of infarct lesions were assessed by DWI scanning. AIS group was further divided into lacunar infarction group, small infarction group,and large infarction group according to the infarction area. The correlation between the number of pDCs and NHISS score and CRP level was also analyzed in AIS group. Results The labsolute number of pDCs and the percentage of pDCPs to circulating blood white cells were significantly lower in AIS group than in the healthy control group (P<0.001). As compared with lacunar infarction group, the number of pDCPs decreased significantly in large infarction group. The number of pDCPs was negatively correlated with the levels of CRP and the NIHSS score. Conclutions Patients with AIS has a decreased level of circulating pDCs, which may be involved in the gathering of circulating pDCs in the infarcted brain to trigger cerebral immune reaction.