CAJ | 학술논문

目的：探讨肿瘤抑制因子p53和生长抑制因子p33ING1b在人类银屑病和基底细胞癌（basal cell carcinoma， BCC）中的表达情况及临床意义。方法：采用免疫组织化学Envision方法检测p53和p33ING1b在36例寻常型银屑病皮损（银屑病组）、28例BCC皮损（BCC组）和14例正常表皮（正常对照组）中的蛋白表达。结果：p53在正常对照组、银屑病组和BCC组中表达递增，p33ING1b在3组中表达递减，组间比较差异均有显著性（均P＜0．05）。银屑病组和BCC组中，p53与p33ING1b之间均存在显著正相关（均P＜0．05）。结论：p53和p33ING1b协同作用于增生性皮肤病的局部皮损，是细胞异常增殖的重要机制之一。
목적：탐토종류억제인자p53화생장억제인자p33ING1b재인류은설병화기저세포암（basal cell carcinoma， BCC）중적표체정황급림상의의。방법：채용면역조직화학Envision방법검측p53화p33ING1b재36례심상형은설병피손（은설병조）、28례BCC피손（BCC조）화14례정상표피（정상대조조）중적단백표체。결과：p53재정상대조조、은설병조화BCC조중표체체증，p33ING1b재3조중표체체감，조간비교차이균유현저성（균P＜0．05）。은설병조화BCC조중，p53여p33ING1b지간균존재현저정상관（균P＜0．05）。결론：p53화p33ING1b협동작용우증생성피부병적국부피손，시세포이상증식적중요궤제지일。
Objective To discuss the expressions and clinical significance of p53 and p33ING1b in human psoriasis and basal cell carcinoma (BCC). Methods Immunohistochemistry EnVision technique was used to detect the expressions of p53 and p33ING1b in samples of 36 psoriasis vulgaris, 28 BCC and 14 normal skins. Results The expression of p53 increased while p33ING1b had a degressive expression in the control group, the psoriasis group and the BCC group. It was found significant statistical difference between the two groups (all P < 0.05). Prominent positive correlation between p53 and p33ING1b were found in both psoriasis group and BCC group (all P<0.05). Conclusions p53 coacts with p33ING1b at local lesions of abnormal proliferative diseases . It′s one of the most prominent mechanisms contributing to deviant cell proliferation.