CAJ | 학술논문

目的：比较血清MMP-2、TIMP-2、TIMP-1、锌、铜及前胶原末端肽的表达，探讨腹股沟疝的发病机制。方法：以在我院行疝修补术患者为研究对象，其中直疝35例；斜疝35例；复发疝17例；正常对照35例。收集各组病人血清标本，对血清指标进行检测。结果：直疝及复发疝组病人血清MMP-2水平显著高于正常组及斜疝组（P＜0．05），尤其为复发疝；血清TIMP-2及TIMP-1水平在直疝和复发疝明显低于正常组及斜疝组（ P＜0．05）；血清铜和锌含量在各组无显著性差异；直疝及复发疝组血清前胶原末端肽PⅠCP/PⅢNP比值显著低于正常组及斜疝组，（ P＜0．05）。结论：和结缔组织代谢相关指标MMP-2、TIMP-2、TIMP-1及PICP/PⅢNP 的改变参与了直疝的发生，并和疝术后复发密切相关。
목적：비교혈청MMP-2、TIMP-2、TIMP-1、자、동급전효원말단태적표체，탐토복고구산적발병궤제。방법：이재아원행산수보술환자위연구대상，기중직산35례；사산35례；복발산17례；정상대조35례。수집각조병인혈청표본，대혈청지표진행검측。결과：직산급복발산조병인혈청MMP-2수평현저고우정상조급사산조（P＜0．05），우기위복발산；혈청TIMP-2급TIMP-1수평재직산화복발산명현저우정상조급사산조（ P＜0．05）；혈청동화자함량재각조무현저성차이；직산급복발산조혈청전효원말단태PⅠCP/PⅢNP비치현저저우정상조급사산조，（ P＜0．05）。결론：화결체조직대사상관지표MMP-2、TIMP-2、TIMP-1급PICP/PⅢNP 적개변삼여료직산적발생，병화산술후복발밀절상관。
Objective:To investigate the expression of MMP-2, TIMP-2, TIMP-1, copper, zinc and terminal propeptides of precollagen in the serum of inguinal hernia and explore the pathogenesis of the dis-ease.Method:The samples were collected from inguinal hernia patients ( direct n=35, indirect n=35, re-current n=17) and from healthy controls ( n=35) .The indicators in serum were measured according to the instruction books of the reagent kits .Result:Serum levels of MMP-2 in direct and recurrent hernia patients were higher than indirect hernia patients and controls (P<0.05).TIMP-2 and TIMP-1 were lower(P<0. 05).Serum levels of Cu and Zn in four groups (especially the recurrent hernia group) have no significant difference.The results of serum PICP/PⅢNP were lower in direct and recurrent groups compared to indirect group and controls(P<0.05).Conclusion:The changes of serum MMP-2, TIMP-2, TIMP-1 and PICP/PⅢNP might be associated with the development of direct and recurrent inguinal hernia .