CAJ | 학술논문

目的：观察育真熄风汤对帕金森病模型小鼠行为学的影响。方法：在1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）诱导的PD小鼠模型基础上，随机分为空白对照组、模型组、中药治疗组和阳性对照组，采用爬杆实验、悬挂实验、游泳实验观察育真熄风汤对PD小鼠行为变化的影响。结果：PD模型组小鼠爬杆实验、悬挂实验及游泳实验障碍中，育真熄风汤能显著缩短小鼠爬杆时间并增加小鼠悬挂能力及游泳能力（ P＜0．01）。结论：育真熄风汤能明显改善MPTP 诱导所致PD模型小鼠的运动协调能力。
목적：관찰육진식풍탕대파금삼병모형소서행위학적영향。방법：재1-갑기-4-분기-1，2，3，6-사경필정（MPTP）유도적PD소서모형기출상，수궤분위공백대조조、모형조、중약치료조화양성대조조，채용파간실험、현괘실험、유영실험관찰육진식풍탕대PD소서행위변화적영향。결과：PD모형조소서파간실험、현괘실험급유영실험장애중，육진식풍탕능현저축단소서파간시간병증가소서현괘능력급유영능력（ P＜0．01）。결론：육진식풍탕능명현개선MPTP 유도소치PD모형소서적운동협조능력。
Objective:To observe the effect of Yuzhenxifeng decoction on action in PD mouse models . Method:To observe the behavior changes through the climbing pole ,suspension and swimming test with pre-paring PD model mice with MPTP .Result:Compared with model group mice , Yuzhenxifeng decoction can shorten the time of climbing pole and enhance the capacity of suspension and swimming test .Conclusion:Yuzhenxifeng decoction can improve the ability of somatic coordanation of mice .It can improve the action in PD mouse models.