CAJ | 학술논문

目的：探讨定期监测心电图和心肌酶对早期发现抗精神病药心脏副作用的意义。方法：以2013年1月至10月住院精神分裂症患者为对象，随机分为两组，研究组49例按计划每周1次定期监测心电图及血清谷草转氨酶（ AST）、乳酸脱氢酶（ LDH）、肌酸磷酸激酶同工酶（ CPK-MB）等3项心肌酶，连续观察4周，而对照组51例按常规仅于治疗前和治疗4周末各检查一次，然后，比较两组4周累计心电图异常检出率、4周累计AST、LDH、CPK-MB异常检出率及异常患者心肌酶检测值和发现时间的差异。结果：研究组4周累计心电图异常检出率（26．5％）显著高于对照组（9．8％，P＜0．05），发现时间（10．2±2．6）d显著早于对照组（14．3±2．9d，P＜0．01）。研究组4周累计AST、LDH、CPK-MB异常检出率显著高于对照组（P＜0．05），异常患者检测值显著低于对照组（P＜0．01）。结论：定期监测心电图和心肌酶，有利于早期发现抗精神病药的心脏副作用。
목적：탐토정기감측심전도화심기매대조기발현항정신병약심장부작용적의의。방법：이2013년1월지10월주원정신분렬증환자위대상，수궤분위량조，연구조49례안계화매주1차정기감측심전도급혈청곡초전안매（ AST）、유산탈경매（ LDH）、기산린산격매동공매（ CPK-MB）등3항심기매，련속관찰4주，이대조조51례안상규부우치료전화치료4주말각검사일차，연후，비교량조4주루계심전도이상검출솔、4주루계AST、LDH、CPK-MB이상검출솔급이상환자심기매검측치화발현시간적차이。결과：연구조4주루계심전도이상검출솔（26．5％）현저고우대조조（9．8％，P＜0．05），발현시간（10．2±2．6）d현저조우대조조（14．3±2．9d，P＜0．01）。연구조4주루계AST、LDH、CPK-MB이상검출솔현저고우대조조（P＜0．05），이상환자검측치현저저우대조조（P＜0．01）。결론：정기감측심전도화심기매，유리우조기발현항정신병약적심장부작용。
Objective:To explore the significance of periodically testing electrocardiogram and cardiac muscle enzymes in discovering cardiac side-effects early due to antipsychotics .Method: From January and October in 2013, inpatients with schizophrenia were randomly divided into two groups .The study group ( n=49) were tested electrocardiogram and such three cardiac muscle enzymes as serum aspartate aminotrans -ferase (AST),lactate dehydrogenase (LDH),creatine phosphokinase-MB(CPK-MB) once a week for 4 weeks.The control group(n=51) were routinely tested only before and after four weeks ’ treatment.Then, the differences between the two groups were compared on the total four weeks ’ incidence of abnormal electro-cardiogram and abnormal AST,LDH,CPK-MB and discover time.Result:In the study group,the total four weeks ’ incidence of abnormal electrocardiogram ( 26.5%) showed significantly higher than that in the control one (9.8%,P<0.05),but,the discover time (10.2±2.6 days) showed significantly earlier than that in the control group (14.3±2.9 days,P<0.01).The total four weeks’ incidences of abnormal AST,LDH,CPK-MB in the study group were significantly higher than those in the control group ( P<0.05) , and the detection lev-els showed significantly lower than those in the control group (P<0.01).Conclusion:It’s helpful to period-ically test electrocardiogram and cardiac muscle enzymes in early discovering cardiac side -effects due to anti-psychotics.