CAJ | 학술논문

目的：探讨PTEN基因缺失和p53基因突变在鼻咽癌中的表达及临床意义。方法：本实验以50例鼻咽癌标本作为病例组，以50例正常子鼻咽部组织作为对照组，应用免疫组织化学技术检测二组中PTEN和p53的表达，分析其不同临床病理特征中的意义及对预后的判断价值。结果：病例组PTEN阴性24例，对照组阴性0例，两组比较差异有显著的统计学意义（P＜0．01），Ⅲ期和Ⅳ期以及有淋巴结转移的患者PTEN 阴性比例明显高于PTEN 阳性患者，差异有有显著的统计学意义（ P＜0．01），病例组PTEN阳性38例，对照组阳性22例，两组比较差异有显著的统计学意义（P＜0．01），有淋巴结转移的患者p53阳性比例明显高于p53阴性患者，差异有有显著的统计学意义（ P＜0．01）。结论：PTEN基因缺失和p53基因突变与鼻咽癌发生和发展密切相关。
목적：탐토PTEN기인결실화p53기인돌변재비인암중적표체급림상의의。방법：본실험이50례비인암표본작위병례조，이50례정상자비인부조직작위대조조，응용면역조직화학기술검측이조중PTEN화p53적표체，분석기불동림상병리특정중적의의급대예후적판단개치。결과：병례조PTEN음성24례，대조조음성0례，량조비교차이유현저적통계학의의（P＜0．01），Ⅲ기화Ⅳ기이급유림파결전이적환자PTEN 음성비례명현고우PTEN 양성환자，차이유유현저적통계학의의（ P＜0．01），병례조PTEN양성38례，대조조양성22례，량조비교차이유현저적통계학의의（P＜0．01），유림파결전이적환자p53양성비례명현고우p53음성환자，차이유유현저적통계학의의（ P＜0．01）。결론：PTEN기인결실화p53기인돌변여비인암발생화발전밀절상관。
Objective:To study clinical significance of deletion of PTEN gene and mutation of p 53 gene in nasopharyngeal carcinoma .Method: 50 cases with nasopharyngeal carcinoma were collected as case group,50 cases with normal nasopharyngeal as control group .and then analyzed the expressions of PTEN and p53 in the two groups by immunohistochemisty .The different clinical characteristic were analyzed .Result:PTEN deletion in 24 cases in case group , None of cases in PTEN deletion in control group , the difference was significant statistical significance ( P<0.01 ) .Ⅲ and Ⅳ and lymph node metastasis was significantly higher than the proportion in PTEN-negative higher than PTEN-positive patients , There's a significant difference (P<0.01), PTEN-positive was 38 cases in case group, 22 cases of positive control group, the difference was significant statistical significance ( P<0.01) , lymph node metastasis p 53 in positive-negative patients were higher than p53-negative patients,There's a significant difference (P<0.01).Conclusion:Deletion of PTEN gene and mutation of p 53 gene correlation with carcinogenesis and progression in nasopha-ryngeal carcinoma .