CAJ | 학술논문

目的：观察柴芍冲剂对偏头痛患者血小板和血浆中一氧化氮（NO）、一氧化氮合酶（NOS）系统的影响，探讨柴芍冲剂治疗偏头痛的机制。方法：分别测定偏头痛患者不同时期血小板、血浆NO生成量和NOS含量，并与健康组相对照。结果：在偏头痛发作期组血浆NO生成量和NOS含量均高于健康者组（P<0.01），发作期组高于间歇期组（P<0.01）。而偏头痛发作期组和间歇期组血小板NO生成量和NOS含量均高于健康者组（P<0.01）；但在该药作用下，血小板血浆NO生成量和NOS含量减少（P<0.01或P<0.05）。结论：血浆和血小板NO、NOS系统在偏头痛发病中可能有重要作用，柴芍冲剂对此系统起调节作用。
목적：관찰시작충제대편두통환자혈소판화혈장중일양화담（NO）、일양화담합매（NOS）계통적영향，탐토시작충제치료편두통적궤제。방법：분별측정편두통환자불동시기혈소판、혈장NO생성량화NOS함량，병여건강조상대조。결과：재편두통발작기조혈장NO생성량화NOS함량균고우건강자조（P<0.01），발작기조고우간헐기조（P<0.01）。이편두통발작기조화간헐기조혈소판NO생성량화NOS함량균고우건강자조（P<0.01）；단재해약작용하，혈소판혈장NO생성량화NOS함량감소（P<0.01혹P<0.05）。결론：혈장화혈소판NO、NOS계통재편두통발병중가능유중요작용，시작충제대차계통기조절작용。
Objective:To observe influence of Chaishao granules on contents of NO and NOS synthase in migraine plasma and platelets of patients. Methods:Platelets, plasma NO production and NOS content in different period were recorded to compare with these in the healthy group. Results:Plasma NO production and NOS content in migraine attack group were higher than that in the healthy (P<0.01), the data in the attack group were higher than that in the intermittent group (P<0.01). While plasma NO production and NOS content in the migraine attack group and the intermittent group were higher than in the healthy (P<0.01); platelets, plasma NO production and NOS content were slow down with Chaishao granules playing a role (P<0.01 or P<0.05). Conclusion:Chaishao granules can adjust the system of NOS and NO synthase of plasma and platelets which play an important role in migraine onset.