CAJ | 학술논문

目的：探讨四逆散合痛泻要方加味对肠易激综合征（IBS ）患者血清5-羟色胺（5-H T ）表达水平的影响。方法选择2012年1月至2013年1月该院脾胃科诊治的60例腹泻型IBS患者为研究对象，并随机分为两组，对照组给予口服曲美布汀＋三联活菌，观察组给予四逆散合痛泻要方加味治疗，观察治疗前后主要症状积分及血清5-HT水平的变化。结果治疗1个疗程后，两组患者腹痛、腹泻、腹胀、大便急迫、肛门坠胀等主要症状积分及5-HT水平均较治疗前有明显降低，差异有统计学意义（P＜0．05），且上述指标观察组明显低于对照组，差异有统计学意义（ P＜0．05）；观察组治疗总有效率为83．33％，明显高于对照组的60．00％，差异有统计学意义（ P＜0．05）。结论四逆散合痛泻要方加味可以调节5-HT的分泌，改善胃肠道运动紊乱和肠道分泌异常情况。
목적：탐토사역산합통사요방가미대장역격종합정（IBS ）환자혈청5-간색알（5-H T ）표체수평적영향。방법선택2012년1월지2013년1월해원비위과진치적60례복사형IBS환자위연구대상，병수궤분위량조，대조조급여구복곡미포정＋삼련활균，관찰조급여사역산합통사요방가미치료，관찰치료전후주요증상적분급혈청5-HT수평적변화。결과치료1개료정후，량조환자복통、복사、복창、대편급박、항문추창등주요증상적분급5-HT수평균교치료전유명현강저，차이유통계학의의（P＜0．05），차상술지표관찰조명현저우대조조，차이유통계학의의（ P＜0．05）；관찰조치료총유효솔위83．33％，명현고우대조조적60．00％，차이유통계학의의（ P＜0．05）。결론사역산합통사요방가미가이조절5-HT적분비，개선위장도운동문란화장도분비이상정황。
Objective To investigate effects of Sinisanhetong decoction on 5-HT in patients with irritable bow-el syndrome (IBS ) .Methods Sixty cases of diarrhea-predominant IBS patients were randomly divided into two groups ,30 cases in each group ,all cases in the control group were treated with Trimebutine + triple viable ,and those in the observation group treated with Sinisanhetong decoction ,the main symptom scores and serum 5-HT level chan-ges were compared between the two groups before and after treatment .Results After one course of treatment ,the abdominal pain ,diarrhea ,bloating ,stool urgency ,anal and other major symptom scores and serum concentration of 5-HT in the two groups were significantly lower than those before treatment ,and those in the the observation group were lower than those in the control group ,the differences were statistically significant (P<0 .05);The total effective rate in the observation group was 83 .33% ,and it was significantly higher than the 60 .00% in the the control group , the difference was statistically significant (P<0 .05) .Conclusion Sinisanhetong decoction can regulate the normal regulation of 5-HT secretion in patients with IBS ,and it can improve the gastrointestinal motility disorders and intes-tinal secretion abnormalities .