检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
11期
1458-1461
,共4页
RBC-Y%RET-Y%铁缺乏%可溶性转铁蛋白受体%肾性贫血
RBC-Y%RET-Y%鐵缺乏%可溶性轉鐵蛋白受體%腎性貧血
RBC-Y%RET-Y%철결핍%가용성전철단백수체%신성빈혈
RBC-Y%RET-Y%iron deficiency%solubility transferring receptor%renal anemia
目的：探讨RBC-Y和RET-Y在肾性贫血患者铁缺乏监测中的应用价值。方法收集慢性肾衰竭（CRF）引起的肾性贫血组和健康对照组血液标本，分别检测 RBC-Y、RET-Y、铁蛋白（SF）、可溶性转铁蛋白受体（sTfR）等指标，以sTfR＞2．25 mg/L作为铁缺乏的“金标准”，利用 ROC曲线分析RBC-Y、RET-Y和SF等参数在诊断肾性贫血患者铁缺乏的性能。结果肾性贫血组与健康对照组间RBC-Y和RET-Y两参数结果差异有统计学意义（P＜0．001），经ROC曲线分析RBC-Y、RET-Y和SF在诊断肾性贫血患者铁缺乏时曲线下面积分别为0．811、0．780、0．530，当临界值为151．6时，RBC-Y诊断铁缺乏的灵敏度为81．0％，特异性为75．0％；当临界值为1580．5时，RET-Y诊断铁缺乏的灵敏度为74．6％，特异性为75．0％；当临界值为96μg/L时，SF诊断铁缺乏的灵敏度为61．9％，特异性为58．3％。结论 RBC-Y和RET-Y可作为CRF引起的肾性贫血患者铁缺乏的诊断指标。
目的：探討RBC-Y和RET-Y在腎性貧血患者鐵缺乏鑑測中的應用價值。方法收集慢性腎衰竭（CRF）引起的腎性貧血組和健康對照組血液標本，分彆檢測 RBC-Y、RET-Y、鐵蛋白（SF）、可溶性轉鐵蛋白受體（sTfR）等指標，以sTfR＞2．25 mg/L作為鐵缺乏的“金標準”，利用 ROC麯線分析RBC-Y、RET-Y和SF等參數在診斷腎性貧血患者鐵缺乏的性能。結果腎性貧血組與健康對照組間RBC-Y和RET-Y兩參數結果差異有統計學意義（P＜0．001），經ROC麯線分析RBC-Y、RET-Y和SF在診斷腎性貧血患者鐵缺乏時麯線下麵積分彆為0．811、0．780、0．530，噹臨界值為151．6時，RBC-Y診斷鐵缺乏的靈敏度為81．0％，特異性為75．0％；噹臨界值為1580．5時，RET-Y診斷鐵缺乏的靈敏度為74．6％，特異性為75．0％；噹臨界值為96μg/L時，SF診斷鐵缺乏的靈敏度為61．9％，特異性為58．3％。結論 RBC-Y和RET-Y可作為CRF引起的腎性貧血患者鐵缺乏的診斷指標。
목적：탐토RBC-Y화RET-Y재신성빈혈환자철결핍감측중적응용개치。방법수집만성신쇠갈（CRF）인기적신성빈혈조화건강대조조혈액표본，분별검측 RBC-Y、RET-Y、철단백（SF）、가용성전철단백수체（sTfR）등지표，이sTfR＞2．25 mg/L작위철결핍적“금표준”，이용 ROC곡선분석RBC-Y、RET-Y화SF등삼수재진단신성빈혈환자철결핍적성능。결과신성빈혈조여건강대조조간RBC-Y화RET-Y량삼수결과차이유통계학의의（P＜0．001），경ROC곡선분석RBC-Y、RET-Y화SF재진단신성빈혈환자철결핍시곡선하면적분별위0．811、0．780、0．530，당림계치위151．6시，RBC-Y진단철결핍적령민도위81．0％，특이성위75．0％；당림계치위1580．5시，RET-Y진단철결핍적령민도위74．6％，특이성위75．0％；당림계치위96μg/L시，SF진단철결핍적령민도위61．9％，특이성위58．3％。결론 RBC-Y화RET-Y가작위CRF인기적신성빈혈환자철결핍적진단지표。
Objective To explore the clinical value of RBC-Y and RET-Y in monitoring the iron deficiency of the patients who suffer with renal anemia .Methods Blood samples were collected from patients with renal anemia of CRF and normal control individuals ,then RBC-Y ,RET-Y ,SF and sTfR were detected respectively and sTfR >2 .25 mg/L was regarded as "gold standard"of the iron deficiency ,using ROC curve to analyze RBC-Y ,RET-Y and SF for the diagnosis of the iron deficiency of the patients who suffer with renal anemia was studied .Results There are sig-nificant differences in RBC-Y and RET-Y between renal anemia group and control group .The RBC-Y ,RET-Y and SF area under the ROC curve are 0 .811 ,0 .780 ,0 .530 ,the sensitivity of RBC-Y in diagnosing iron deficiency is 81 .0%and specificity is 75 .0% when the critical value is 151 .6 ;sensitivity of RET-Y is 74 .6% and specificity is 75 .0%when the critical value is 1 580 .5;sensitivity of SF is 61 .9% and specificity is 58 .3% when the critical value is 96μg/L .Conclusion RBC-Y and RET-Y could be used as an indicator of iron deficiency in patients with renal anemia of CRF .
