CAJ | 학술논문

　　目的建立气相色谱法测定布南色林中残留溶剂含量的方法。方法采用6%氰丙基苯基-94%二甲基聚硅氧烷为固定液的毛细管柱（DB-624，0.53 mm×30 m，3.0μm），程序升温，初始温度50℃，保持5 min，以20℃/min的速率升温至200℃，保持5 min；氢火焰离子化检测器（FID），检测器温度250℃，进样口温度220℃，载气为氮气，流速2 mL/min，进样体积1 mL。外标法计算残留溶剂的含量。结果5种有机溶剂进样浓度与峰面积呈良好线性关系，相关系数均大于0.9990，加样回收率在97.6%~102.9%之间。结论此法准确可靠，灵敏度高，可用于布南色林中残留溶剂的测定。
　　목적건립기상색보법측정포남색림중잔류용제함량적방법。방법채용6%청병기분기-94%이갑기취규양완위고정액적모세관주（DB-624，0.53 mm×30 m，3.0μm），정서승온，초시온도50℃，보지5 min，이20℃/min적속솔승온지200℃，보지5 min；경화염리자화검측기（FID），검측기온도250℃，진양구온도220℃，재기위담기，류속2 mL/min，진양체적1 mL。외표법계산잔류용제적함량。결과5충유궤용제진양농도여봉면적정량호선성관계，상관계수균대우0.9990，가양회수솔재97.6%~102.9%지간。결론차법준학가고，령민도고，가용우포남색림중잔류용제적측정。
Objective To establish a GC method for the determination of residual solvents in blonanserin. Methods DB-624 chromatographic column (coated with 6%cyanopropylphenyl-94%dimethylpolysiloxane, length 30 m, I.D. 0.53 mm, film 3.0μm) was adopted. The column temperature was programmed: kept at 50℃for 5 min, and then increased by 20℃/min to 200℃for 5 min, and kept for 5 min. The temperature of FID detector was 250℃and the temperature of inlet was 220℃. The carrier gas was nitrogen at a flow rate of 2 mL/min. The injection volume was 1 mL. Contents of residual solvents were calculated according to the external standard method. Results The calibration curves of five solvents all showed good linearity in a detected concentration range(r>0.9990), the range of average recovery was 97.6%~102.9%. Conclusion The method was accurate, reliable and sensitive, and can be used for assay of residual organic solvents in blonanserin.