CAJ | 학술논문

　　目的研究湿热灭菌前后玻璃酸钠注射液中玻璃酸钠的分子量及构象。方法采用温度121℃，灭菌时间分别为12，15，18，25 min。结果灭菌时间的延长与分子量的下降呈正相关性，样品的构象因子值始终为0.5~0.7。结论灭菌后产品分子量符合国家标准；灭菌过程中玻璃酸钠分子量均一性较好；灭菌操作对玻璃酸钠分子无规则线团构象的影响不大。
　　목적연구습열멸균전후파리산납주사액중파리산납적분자량급구상。방법채용온도121℃，멸균시간분별위12，15，18，25 min。결과멸균시간적연장여분자량적하강정정상관성，양품적구상인자치시종위0.5~0.7。결론멸균후산품분자량부합국가표준；멸균과정중파리산납분자량균일성교호；멸균조작대파리산납분자무규칙선단구상적영향불대。
Objective To investigate the impact of steam sterilization on the molecular weight and conformation of sodium hyaluronate. Methods The sterilization was carried out at 121℃with duration of 12, 15, 18, 25 minutes, respectively. Results The extension of sterilization time and the decrease of molecular weight showed a positive correlation, the conformation factor values were always between 0.5-0.7. Conclusion The molecular weight of sodium hyaluronate after sterilization is complied with national standards;the molecular weight distribution of sodium hyaluronate in the sterilization process is rather limited;sterilization has little effect on the random coil conformation of sodium hyaluronate.