CAJ | 학술논문

　　人类半胱氨酸蛋白酶抑制剂基因（cystatin E/M or CST6），又称胱抑C，最初是从转移性乳腺癌细胞中分离出来的一种具有抑制半胱氨酸蛋白酶作用的新基因。有研究发现CST6基因在浸润性乳腺癌、宫颈癌、转移性前列腺癌以及神经胶质脑瘤中表达均有下调，具有抑癌基因的潜能，并且还发现造成该基因表达下调的原因除了基因突变、基因缺失以外，表观遗传修饰的作用更为普遍，而且后者导致的基因沉默可以通过药物逆转。现今有一些关于CST6与癌症发生发展的研究取得了一定的成果。本文综述了CST6基因的功能研究以及其异常甲基化与癌症发生发展关系的研究进展，有望为揭示肿瘤的发生机制提供新的思路，为肿瘤的预防、诊断、治疗提供新的靶点。
　　인류반광안산단백매억제제기인（cystatin E/M or CST6），우칭광억C，최초시종전이성유선암세포중분리출래적일충구유억제반광안산단백매작용적신기인。유연구발현CST6기인재침윤성유선암、궁경암、전이성전렬선암이급신경효질뇌류중표체균유하조，구유억암기인적잠능，병차환발현조성해기인표체하조적원인제료기인돌변、기인결실이외，표관유전수식적작용경위보편，이차후자도치적기인침묵가이통과약물역전。현금유일사관우CST6여암증발생발전적연구취득료일정적성과。본문종술료CST6기인적공능연구이급기이상갑기화여암증발생발전관계적연구진전，유망위게시종류적발생궤제제공신적사로，위종류적예방、진단、치료제공신적파점。
CST6 or cystatin E/M is first identified in breast cancer cells, which is a novel tumor suppressor gene inhibiting the function of cysteine proteases. The expression of CST6 gene are obviously down-regulated in breast caner, cervical cancer, metastatic prostate cancer, and glioma. The reason of down-regulation of the expression of CST6, besides gene mutation and gene deletion, is epigenetic modification which is more prevalent. Fortunately, the gene silencing caused by the latter reason can be reversed through drugs. In this review, the functional research process of CST6 gene and the relationship between CST6 abnormal methylation and the occurrence and development of carcinoma are summarized based on the numerous reports of CST6, which are excepted to provide new ideas about the occurrence mechanism of cancer, and also provide a new target for cancer prevention, diagnosis and treatment.