CAJ | 학술논문

目的：探讨C12肿瘤标志物蛋白芯片监测系统中12种肿瘤标志物在大肠癌患者血清中的表达情况，筛选出对诊断最有意义的标志物。方法采用c12肿瘤标志物蛋白芯片检测系统测定60例大肠癌和40例健康对照者血清中12种肿瘤标志物，找出与大肠癌相关性最强的肿瘤标志物，计算各标志物组合方式对提高诊断率的贡献。结果 CEA＋CA199＋CA242＋Bete-HCG组合为诊断大肠癌效率最高的组合，联合检测可以提高诊断的灵敏度。最优诊断组合与患者年龄、性别、分化程度、病理类型、淋巴结转移、分期无明显相关。结论血清中CEA＋CA199＋CA242＋Bete-HCG联合检测可以作为大肠癌诊断的指标，联合检测可以提高诊断效率。
목적：탐토C12종류표지물단백심편감측계통중12충종류표지물재대장암환자혈청중적표체정황，사선출대진단최유의의적표지물。방법채용c12종류표지물단백심편검측계통측정60례대장암화40례건강대조자혈청중12충종류표지물，조출여대장암상관성최강적종류표지물，계산각표지물조합방식대제고진단솔적공헌。결과 CEA＋CA199＋CA242＋Bete-HCG조합위진단대장암효솔최고적조합，연합검측가이제고진단적령민도。최우진단조합여환자년령、성별、분화정도、병리류형、림파결전이、분기무명현상관。결론혈청중CEA＋CA199＋CA242＋Bete-HCG연합검측가이작위대장암진단적지표，연합검측가이제고진단효솔。
Objective The purpose of this study is to explore the expression of 12 tumor Markerss in the serum of colon cancer patients by C 12 tumor marker protein chip ,screening most valuable Markers for diagnosis . Methods C12 tumor Marker of protein chips were used for 12 sorts of tumor marker detection among 60 CRC patients and 40 healthy controls ,address the most valuable tumor marker relative to colon cancer and contribution of combinations effect on diagnosis .Result CEA+CA199+CA242+Bete-HCG combination diagnosis has the highest effectivity and diagnosis sensitivity was greatly improved by combination detection .The optimized diagno-sis showed no significant tendency to be correlated with age ,sex,differentiation stage,pathology,Lymph node me-tastasis,clinical stage.Conclusion It is of importance to use sera CEA +CA199+CA242+Bete-HCG detec-tion as markers for colon cancer diagnosis ,which may improve diagnosis efficiency .